Auhtors: Heng Y, Zhu X, Lin H, Jingyu M, Ding X, Tao L, Lu L PMID: 36864443 PMCID: PMC9983170 DOI: 10.1186/s12967-023-03910-4 Abstract Background: Tumor-associated macrophages (TAMs) are major component in the tumor microenvironment (TME) and play regulatory role in tumor progression. We aimed to investigate the infiltration and prognostic value of TAMs in laryngeal squamous [...]

Auhtors: Kumari N, Choi SH PMID: 35183252 PMCID: PMC8857848 DOI: 10.1186/s13046-022-02272-x Abstract Cancer immunotherapy has emerged as a novel cancer treatment, although recent immunotherapy trials have produced suboptimal outcomes, with durable responses seen only in a small number of patients. The tumor microenvironment (TME) has been shown to be responsible for tumor immune escape and [...]

Auhtors: Debebe A, Medina V, Chen CY, Mahajan IM, Jia C, Fu D, et al. PMID: 34591416 PMCID: PMC8958883 DOI: 10.20892/j.issn.2095-3941.2021.0306 Abstract The Wnt/β-catenin signaling pathway regulates many aspects of tumor biology, and many studies have focused on the role of this signaling pathway in tumor cells. However, it is now clear that tumor development [...]

Auhtors: Komohara Y, Niino D, Ohnishi K, Ohshima K, Takeya M PMID: 34298810 PMCID: PMC8304632 DOI: 10.3390/cancers13143597 Abstract The tumor microenvironment includes dendritic cells, T-cytotoxic, T-helper, reactive B-lymphoid cells and macrophages; these reactive cells could interplay with malignant cells and promote tumor growth and survival. Among its cellular components, tumor-associated macrophages (TAM) represent a component [...]

Auhtors: Pan Y, Yu Y, Wang X, Zhang T PMID: 33365025 PMCID: PMC7751482 DOI: 10.3389/fimmu.2020.583084 Abstract Tumor-associated macrophages (TAMs) represent one of the main tumor-infiltrating immune cell types and are generally categorized into either of two functionally contrasting subtypes, namely classical activated M1 macrophages and alternatively activated M2 macrophages. The former typically exerts anti-tumor functions, [...]

Auhtors: Liu W, Wang W, Wang X, Xu C, Zhang N, Di W PMID: 31866467 DOI: 10.1016/j.canlet.2019.12.024 Abstract Despite the high response rate after surgery and platinum-combination chemotherapy, treatment of ovarian cancer remains challenging due to tumor recurrence and metastasis. Tumor-associated macrophages (TAMs) have been linked to cancer progression and metastasis. However, the impact of [...]

Auhtors: Li X, Liu R, Su X, Pan Y, Han X, Shao C, Shi Y PMID: 31805946 PMCID: PMC6894344 DOI: 10.1186/s12943-019-1102-3 Abstract Cancer immunotherapies that engage immune cells to fight against tumors are proving to be powerful weapons in combating cancer and are becoming increasingly utilized in the clinics. However, for the majority of patients [...]

Auhtors: Yin Z, Ma T, Huang B, Lin L, Zhou Y, Yan J, et al. PMID: 31307515 PMCID: PMC6631643 DOI: 10.1186/s13046-019-1313-x Abstract Background: Exosomes from cancer cells or immune cells, carrying bio-macromolecules or microRNAs (miRNAs), participate in tumor pathogenesis and progression by modulating microenvironment. Our study aims to investigate the role of these microRNA-501-3p (miR-501-3p) [...]

Auhtors: D'Errico G, Alonso-Nocelo M, Vallespinos M, Hermann PC, Alcalá S, García CP, et al. PMID: 30936462 DOI: 10.1038/s41388-019-0803-9 Abstract Pancreatic ductal adenocarcinoma (PDAC) is an inherently chemoresistant tumor. Chemotherapy leads to apoptosis of cancer cells, and in previous studies we have shown that tumor-associated macrophage (TAM) infiltration increases following chemotherapy in PDAC. Since one [...]

Auhtors: Wang W, Liu Y, Guo J, He H, Mi X, Chen C, et al. PMID: 30563983 PMCID: PMC6299090 DOI: 10.1038/s41389-018-0106-y Abstract Tumor-associated macrophages (TAMs), the main part of immune cells in tumor microenvironment (TME), play a potent role in promoting tumorigenesis through mechanisms such as stimulating angiogenesis, enhancing tumor migration and suppressing antitumor immunity. [...]