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Auhtors: Cassetta L, Fragkogianni S, Sims AH, Swierczak A, Forrester LM, Zhang H, et al. PMID: 30930117 PMCID: PMC6472943 DOI: 10.1016/j.ccell.2019.02.009 Abstract The roles of tumor-associated macrophages (TAMs) and circulating monocytes in human cancer are poorly understood. Here, we show that monocyte subpopulation distribution and transcriptomes are significantly altered by the presence of endometrial and [...]
Categories: Cancer Care
Auhtors: Wang W, Liu Y, Guo J, He H, Mi X, Chen C, et al. PMID: 30563983 PMCID: PMC6299090 DOI: 10.1038/s41389-018-0106-y Abstract Tumor-associated macrophages (TAMs), the main part of immune cells in tumor microenvironment (TME), play a potent role in promoting tumorigenesis through mechanisms such as stimulating angiogenesis, enhancing tumor migration and suppressing antitumor immunity. [...]
Categories: Cancer Care
Auhtors: Klimp AH, Hollema H, Kempinga C, van der Zee AG, de Vries EG, Daemen T PMID: 11585770 Abstract This study investigates whether and to what extent cyclooxygenase type-2 (COX-2) and inducible nitric oxide-synthase (iNOS), both known to have an immunosuppressive effect, are expressed in human ovarian tumors. Because COX-2 and iNOS can be expressed [...]
Categories: Cancer Care