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FLCCC | Front Line COVID-19 Critical Care Alliance
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References

Categories

I-CARE Early Covid (3) I-CARE Flu and RSV (1) I-PREVENT (28) I-RECOVER Long Covid (3) I-RECOVER Post-Vaccine (3) MATH+ (20)

Tags

25-hydroxyvitamin D (2) 25‐HYDROXY VITAMIN D (2) Ambulatory treatment (2) Anti-inflammatory (2) Anti-Inflammatory Agents (1) Anticoagulant (2) Antimicrobial Cationic Peptides (1) Antiparasitic Agents (3) Antiviral (2) Ascorbic Acid (3) Calcifediol (1) Collagen (1) Coronavirus (2) COVID-19 (23) Dithiothreitol (1) Endothelial Barrier (1) Endothelial Permeability (1) Epidemiology (2) Ergocalciferols (1) Famotidine (7) Fixed drug eruption (1) Glucocorticosteroids (3) Heparanase (2) Human immunodeficiency virus (HIV) (1) Hydroxychloroquine (2) Inflammation (4) ivermectin (18) Melatonin (13) Methylprednisol (2) Nitric Oxide (1) Omicron (6) Onchocerciasis (1) pharmacokinetics (1) Pneumonia (2) SARS-CoV-2 (20) Sars-CoV2 (2) Sepsis (3) Septic (2) Spike Protein (5) Stevens–Johnson syndrome (SJS) (1) Tempol (1) viral infection (3) Vitamin C (3) Vitamin D (6) vitamin D 2 (1)
  • Reference: The effect of melatonin on thrombosis, sepsis and mortality rate in COVID-19 patients

    Published On: October 12, 2021

    This study aimed to determine the effect of melatonin on thrombosis, sepsis, and mortality rate in adult patients with severe coronavirus infection (COVID-19).

    Categories: MATH+

    Tags: COVID-19, Melatonin, Sepsis, Thrombosis

  • Reference: Melatonin as adjuvant treatment for coronavirus disease 2019 pneumonia patients requiring hospitalization (MAC-19 PRO): a case series

    Published On: August 11, 2021

    Treatment for coronavirus disease 2019 (COVID19) pneumonia remains empirical and the search for therapies that can improve outcomes continues. Melatonin has been shown to have anti-inflammatory, antioxidant, and immune-modulating effects that may address key pathophysiologic mechanisms in the development and progression of acute respiratory distress syndrome (ARDS), which has been implicated as the likely cause of death in COVID19. We aimed to describe the observable clinical outcomes and tolerability of high-dose melatonin (hdM) given as adjuvant therapy in patients admitted with COVID19 pneumonia.

    Categories:

    Tags: Melatonin

  • Reference: Efficacy of a low dose of melatonin as an adjunctive therapy in hospitalized patients with COVID-19: A randomized, double-blind clinical trial

    Published On: June 23, 2021

    Background: Melatonin has been known as an anti-inflammatory agent and immune modulator that may address progressive pathophysiology of coronavirus disease 2019 (COVID-19).

    Categories: MATH+

    Tags: Adjunctive therapy, Melatonin

  • Reference: Efficacy of high dose vitamin C, melatonin and zinc in Iranian patients with acute respiratory syndrome due to Coronavirus infection: A pilot randomized trial.

    Published On: April 5, 2021

    INTRODUCTION: Our aim was to investigate the efficacy of vitamin C, melatonin, and zinc in patients with severe Covid-19.

    Categories: MATH+

    Tags: Hypoxemia, ICU, Melatonin, Vitamin C

  • Reference: The effects of melatonin supplementation on sleep quality and assessment of the serum melatonin in ICU patients: A randomized controlled trial

    Published On: December 4, 2020

    To evaluate whether the use of exogenous melatonin affects sleep, reduces the prevalence of delirium, and decreases the need for analgosedation and to assess whether serum melatonin indices correlate with exogenous administration in critically ill patients.

    Categories:

    Tags: Central Nervous System Depressants, Melatonin

  • Reference: Melatonin is significantly associated with survival of intubated COVID-19 patients

    Published On: October 18, 2020

    Respiratory distress requiring intubation is the most serious complication associated with coronavirus disease 2019 (COVID-19).

    Categories: MATH+

    Tags: Melatonin

  • Reference: Clinical trials for use of melatonin to fight COVID-19 are urgently needed

    Published On: August 24, 2020

    Konrad Kleszczyński, Andrzej T Slominski, Kerstin Steinbrink, Russel J Reiter PMID: 32847033 PMCID: PMC7551551 DOI: 10.3390/nu12092561 AbstractThe recent pandemic of COVID-19 has already infected millions of individuals and has resulted in the death of hundreds of thousands worldwide. Based on clinical features, pathology, and the pathogenesis of respiratory disorders induced by this and other highly [...]

    Categories: I-PREVENT

    Tags: immune response, Inflammation, Melatonin

  • Reference: ER stress and autophagy induced by SARS-CoV-2: The targer for melatonin treatment

    Published On: June 15, 2020

    Coronavirus disease 19 (COVID-19) is a viral disease caused by the new coronavirus SARS-CoV-2. Like other coronaviral infections, SARS-CoV-2 causes oxidative and ER stress triggering cellular response pathways, mainly PERK and IRE1 branches of the UPR.

    Categories: I-PREVENT

    Tags: aging, autophagy, ER-stress, Melatonin, Sars-CoV2, unfolded protein response (UPR), viral infection

  • Reference: COVID-19: Melatonin as a potential adjuvant treatment

    Published On: June 1, 2020

    This article summarizes the likely benefits of melatonin in the attenuation of COVID-19 based on its putative pathogenesis.

    Categories: I-PREVENT

    Tags: Cytokines, Immunomodulation, Melatonin, Oxidation-reduction, SARS-CoV-2

  • Reference: Therapeutic algorithm for use of melatonin in patients with COVID-19

    Published On: May 15, 2020

    The coronavirus, COVID-19, has infected hundreds of thousands and killed tens of thousands of individuals worldwide. This highly infectious condition continues to ravage the world population and has yet to reach it peak infective rate in some countries.

    Categories: I-PREVENT

    Tags: COVID-19, Melatonin, SARS-CoV-2

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©2020–2023 All Rights Reserved FLCCC Alliance. The information contained or presented on this website is for educational purposes only. Information on this site is NOT intended to serve as a substitute for diagnosis, treatment, or advice from a qualified, licensed medical professional. The facts presented are offered as information only in order to empower you – our protocol is not medical advice – and in no way should anyone infer that we, even though we are physicians, or anyone appearing in any content on this website are practicing medicine, it is for educational purposes only. Any treatment protocol you undertake should be discussed with your physician or other licensed medical professional. Seek the advice of a medical professional for proper application of ANY material on this site or our program to your specific situation. NEVER stop or change your medications without consulting your physician. If you are having an emergency contact your emergency services: in the USA that’s 911. Please read our complete disclaimers.

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