Authors: Olas B PMID: 35405963 PMCID: PMC9002813 DOI: 10.3390/nu14071350 Abstract Cardiovascular diseases (CVDs) have been the leading cause of death for over 20 years. The main causative factors are believed to be high cholesterol, obesity, smoking, diabetes, and a lack of physical activity. One of the most commonly used treatments is a combination of anticoagulant [...]

Authors: Malone B, Campbell EA PMID: 34518697 DOI: 10.1038/s41594-021-00657-8 Abstract Molnupiravir, a wide-spectrum antiviral that is currently in phase 2/3 clinical trials for the treatment of COVID-19, is proposed to inhibit viral replication by a mechanism known as ‘lethal mutagenesis’. Two recently published studies reveal the biochemical and structural bases of how molnupiravir disrupts the [...]

Authors: Karimi A, Naeini F, Azar VA, Hasanzadeh M PMID: 33940332 DOI: 10.1016/j.phymed.2021.153567 Abstract Background: Sepsis is a life-threatening condition caused by a dysregulated host response to infection. Several studies have indicated that flavonoids exhibit a wide variety of biological actions including free radical scavenging and antioxidant activities. Quercetin, one of the most extensively distributed [...]

Authors: Calis Z, Mogulkoc R, Baltaci AK. PMID: 31288717 DOI: 10.2174/1389557519666190617150051 Abstract The inflammatory process in the human body is a physiological response involving many cellular types and mediators. It results in scar formation to separate the damaged area from the surrounding healthy tissue. Because of increased blood-brain barrier permeability following inflammation, leukocytes infiltrate the [...]

Authors: Henriquez MS, de Tejada Romero MJ PMID: 32486496 PMCID: PMC7352679 doi: 10.3390/nu12061617 Abstract Vitamin D deficiency is a global health problem due to its high prevalence and its negative consequences on musculoskeletal and extra-skeletal health. In our comparative review of the two exogenous vitamin D supplementation options most used in our care setting, we [...]

Nair MP, Kandaswami C, Mahajan S, Chadha KC, Chawda R, Nair H. PMID: 12431781 DOI: 10.1016/s0167-4889(02)00328-2 Abstract Flavonoids are plant metabolites that are dietary antioxidants and exert significant anti-tumor, anti-allergic, anti-inflammatory and anti-viral effects. It is generally accepted that Th-1 derived cytokines such as IL-2, IFNgamma and IL-12 promote cellular immunity while Th-2 derived [...]

Authors: Moballegh Nasery M, Abadi B, Poormoghadam D, Zarrabi A, Keyhanvar P, Tavakol S et al. PMID: PMC7037405 DOI: 10.3390/molecules25030689 Abstract Todays, nano-pharmaceutics is emerging as an important field of science to develop and improve efficacy of different drugs. Although nutraceuticals are currently being utilized in the prevention and treatment of various chronic diseases such [...]

Authors: Chai YS, Chen YQ, Lin SH, Xie K, Wang CJ, Yang YZ. PMID: 32004976 DOI: 10.1016/j.biopha.2020.109946 Abstract Objectives: Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is one type of respiratory failure characterized by rapid onset of widespread inflammation in the lungs. Curcumin has been reported to be an anti-inflammatory factor through enhancing the function [...]

Authors: Gutierrez S, Svahn SL, Johansson ME PMID: 31614433 PMCID: PMC6834330 DOI: 10.3390/ijms20205028 Abstract Alterations on the immune system caused by omega-3 fatty acids have been described for 30 years. This family of polyunsaturated fatty acids exerts major alterations on the activation of cells from both the innate and the adaptive immune system, although [...]

Authors: Kunnumakkara AB, Harsha C, Banik K, Vikkurthi R, Sailo BL, Bordoloi D PMID: 31361978 DOI: 10.1080/17425255.2019.1650914 Abstract Introduction: Since ancient times, turmeric has been used in several folklore remedies against various ailments. The principal component of turmeric is curcumin and its efficacy has been advocated in various in vitro, in vivo and clinical studies [...]