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Riva A, Ronchi M, Petrangolini G, Bosisio S, Allegrini P. PMID: 30328058 PMCID: PMC6418071 DOI: 10.1007/s13318-018-0517-3 Abstract Background and objectives: The importance of quercetin and flavonoids in the diet and as food supplements is well known, and literature studies support their potential use to treat several human diseases. Many beneficial properties have been described [...]
Categories: I-CARE Early Covid, I-CARE Flu and RSV, I-PREVENT, I-RECOVER Post-Vaccine
Tags: quercetin
Inhaled corticosteroids (ICS) have limited efficacy in reducing chronic obstructive pulmonary disease (COPD) exacerbations and increase pneumonia risk, through unknown mechanisms. Rhinoviruses precipitate most exacerbations and increase susceptibility to secondary bacterial infections. Here, we show that the ICS fluticasone propionate (FP) impairs innate and acquired antiviral immune responses leading to delayed virus clearance and previously unrecognised adverse effects of enhanced mucus, impaired antimicrobial peptide secretion and increased pulmonary bacterial load during virus-induced exacerbations. Exogenous interferon-β reverses these effects. FP suppression of interferon may occur through inhibition of TLR3- and RIG-I virus-sensing pathways. Mice deficient in the type I interferon-α/β receptor (IFNAR1−/−) have suppressed antimicrobial peptide and enhanced mucin responses to rhinovirus infection. This study identifies type I interferon as a central regulator of antibacterial immunity and mucus production. Suppression of interferon by ICS during virus-induced COPD exacerbations likely mediates pneumonia risk and raises suggestion that inhaled interferon-β therapy may protect.
Categories: I-CARE Flu and RSV
Tags: Corticosteroids
Authors: Lee CR, Zeldin DC PMID: 26605933 PMCID: PMC5512422 doi: 10.1056/NEJMcibr1511280 Abstract Severe sepsis remains a major public health problem associated with poor clinical outcomes and substantial health care expenditures. Although the number of sepsis cases in the United States exceeds 750,000 per year and sepsis is associated with an estimated mortality rate of 20–30%, [...]
Tags: Sepsis
Authors: Rich GT. PMID: 28165426 doi: 10.3390/nu9020111 PMCID: PMC5331542 Abstract We have studied the uptake of quercetin aglycone into CaCo-2/TC7 cells in the presence and absence of mixed micelles that are present in the human small intestine. The micelles inhibited the transport of quercetin into the cells. To gain an understanding of why this is [...]
Categories: I-CARE Early Covid, I-CARE Flu and RSV, I-PREVENT, I-RECOVER Post-Vaccine
Tags: quercetin
Authors: Rahimi HR, Nedaeinia R, Shamloo AS, Nikdoust S. PMID: 27516979 PMCID: PMC4967834 Abstract Objective: Curcumin is extracted from Curcuma longa and regulates the intracellular signal pathways which control the growth of cancerous cell, inflammation, invasion and apoptosis. Curcumin molecules have special intrinsic features that can target the intracellular enzymes, genome (DNA) and messengers (RNA). [...]
Categories: I-CARE Early Covid, I-CARE Flu and RSV, I-PREVENT, I-RECOVER Post-Vaccine
Tags: Curcumin
Authors: Wang W, Sun C, Mao L, Ma P, Liu F, Yang J. doi: https://doi.org/10.1016/j.tifs.2016.07.004 Abstract Background Quercetin, one of the most well-known flavonoids, has been included in human diet for a long history. The use of quercetin has been widely associated with a great number of health benefits, including antioxidant, anti-inflammatory, antiviral and anticancer [...]
Categories: I-CARE Early Covid, I-CARE Flu and RSV, I-PREVENT, I-RECOVER Post-Vaccine
Tags: quercetin
Authors: Leyva-Lopez N, Gutierrez-Grijalva EP, Ambriz-Perez D. PMID: PMC4926454 DOI: 10.3390/ijms17060921 Abstract High levels of cytokines, such as interleukin (IL)-1β, tumor necrosis factor (TNF)-α and IL-6, are associated with chronic diseases like rheumatoid arthritis, asthma, atherosclerosis, Alzheimer's disease and cancer; therefore cytokine inhibition might be an important target for the treatment of these diseases. Most [...]
Categories: I-CARE Early Covid, I-CARE Flu and RSV, I-PREVENT, I-RECOVER Post-Vaccine
Tags: Cytokines, flavonoids
Authors: van Zuuren EJ, Fedorowicz Z, Schoones J PMID: 27225981 PMCID: PMC6457957 DOI: 10.1002/14651858.CD007628.pub4 Abstract Background: Female pattern hair loss (FPHL), or androgenic alopecia, is the most common type of hair loss affecting women. It is characterised by progressive shortening of the duration of the growth phase of the hair with successive hair cycles, and [...]
Categories: I-CARE Early Covid, I-CARE Flu and RSV
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Authors: Seale LR, Eglini AN, McMichael AJ PMID: 27050696 Abstract 5 α-reductase inhibitors such as finasteride and dutasteride have been studied for the treatment of hair loss in men, with finasteride being the only Food and Drug Administration-approved treatment. Increasingly, in recent years, off-label use of these drugs has been employed in the treatment of [...]
Categories: I-CARE Early Covid, I-CARE Flu and RSV
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Authors: Li Y, Yao J, Han C, Yang J, Chaudhry MT, Wang S et al. PMID: 26999194 doi: 10.3390/nu8030167 Abstract In vitro and some animal models have shown that quercetin, a polyphenol derived from plants, has a wide range of biological actions including anti-carcinogenic, anti-inflammatory and antiviral activities; as well as attenuating lipid peroxidation, platelet [...]
Categories: I-CARE Early Covid, I-CARE Flu and RSV, I-PREVENT, I-RECOVER Post-Vaccine
Tags: quercetin