Authors: Miranda-Massari JR, Toro AP, Loh D, Rodriguez JR, Borges RM PMID: 34947872 PMCID: PMC8708699 DOI: 10.3390/life11121341 Abstract Currently available anti-viral drugs may be useful in reducing the viral load but are not providing the necessary physiological effects to reduce the SARS-CoV-2 complications efficiently. Treatments that provide better clinical outcomes are urgently needed. Vitamin C [...]

Authors: Holford P, Carr AC, Zawari M, Vizcaychipi MP PMID: 34833042 PMCID: PMC8624950 DOI: 10.3390/life11111166 Abstract Severe respiratory infections are characterized by elevated inflammation and generation of reactive oxygen species (ROS) which may lead to a decrease in antioxidants such as vitamin C and a higher requirement for the vitamin. Administration of intravenous vitamin C [...]

Severe respiratory infections are characterized by elevated inflammation and generation of reactive oxygen species (ROS) which may lead to a decrease in antioxidants such as vitamin C and a higher requirement for the vitamin.

INTRODUCTION: Our aim was to investigate the efficacy of vitamin C, melatonin, and zinc in patients with severe Covid-19.

Authors: Fatima S, Zaidi SS, Alsharidah AS, Alijaser FS, Banu N PMID: 33344529 PMCID: PMC7744567 DOI: 10.3389/fvets.2020.585789 Abstract SARS-CoV-2, an epidemic, causes severe stress in both human and animals and may induce oxidative stress (OS) and increases susceptibility to infection. Domestic animals are found infected by their COVID-2 suffering owners. Chronic immobilization stress (CIS), a [...]

Authors: Arslan B, Ergun NU, Topuz S, Semerci SY, Suner N. DOI: 10.2139/ssrn.3682517 Abstract Background: While waiting for vaccine, hygiene measures, social distance and personal protective equipment are the only basic protection against Novel Coronavirus. However, these are not sufficient to protect healthcare workers.This study aimed to evaluate if quercetin and vitamin C could be [...]

Authors: Ahmed AK, Albalawi YS, Shora HA, Abelseed HK, Al-Kattan AN. DOI:10.37179/rijed.000005 Abstract ABSTRACT COVID-19 emerged in Wuhan, China in December 2019, reached epidemic proportions and spread globally as a serious life-threatening pandemic. SARS- Cov-2 is the causative virus that causes severe acute respiratory distress, pneumonia, respiratory failure, and septic shock leading to increased mortality. [...]

Authors: de Melo AF, Homem-de-Mello M PMID: 32792018 PMCID: PMC7424130 DOI: 10.1186/s13054-020-03228-3 Abstract The complete mechanism of action of the SARS-CoV-2 remains unclear. The severity of the disease is probably linked to the “cytokine storm” that leads to the acute respiratory distress syndrome. Cytokine storm is an overwhelming increase of several inflammatory markers at once, [...]

Authors: Fontana F, Cazzato S, Giovanella S, Ballestri M, Leonelli M, Mori G PMID: 32838081 PMCID: PMC7363608 DOI: 10.1016/j.ekir.2020.07.008 Abstract Kidney dysfunction is frequently reported in patients with coronavirus disease 2019 (COVID-19). A recent large cohort study described an incidence of acute kidney injury (AKI) of 36% in patients who were hospitalized with COVID-19; AKI [...]

Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) represents an emergent global threat which is straining worldwide healthcare capacity. As of May 27th, the disease caused by SARS-CoV-2 (COVID-19) has resulted in more than 340,000 deaths worldwide, with 100,000 deaths in the US alone. It is imperative to study and develop pharmacological treatments suitable for the prevention and treatment of COVID-19. Ascorbic acid is a crucial vitamin necessary for the correct functioning of the immune system. It plays a role in stress response and has shown promising results when administered to the critically ill. Quercetin is a well-known flavonoid whose antiviral properties have been investigated in numerous studies. There is evidence that vitamin C and quercetin co-administration exerts a synergistic antiviral action due to overlapping antiviral and immunomodulatory properties and the capacity of ascorbate to recycle quercetin, increasing its efficacy. Safe, cheap interventions which have a sound biological rationale should be prioritized for experimental use in the current context of a global health pandemic. We present the current evidence for the use of vitamin C and quercetin both for prophylaxis in high-risk populations and for the treatment of COVID-19 patients as an adjunct to promising pharmacological agents such as Remdesivir or convalescent plasma.