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Severe respiratory infections are characterized by elevated inflammation and generation of reactive oxygen species (ROS) which may lead to a decrease in antioxidants such as vitamin C and a higher requirement for the vitamin.
Categories: I-PREVENT
Authors: Hasan ZT, AlAtrakji MQ, Mehuaiden AK PMID: 34653660 PMCID: PMC8506572 DOI: 10.1016/j.ijid.2021.10.012 Abstract Objectives: This study aimed to determine the effect of melatonin on thrombosis, sepsis, and mortality rate in adult patients with severe coronavirus infection (COVID-19). Methods: This single-center, prospective, randomized clinical trial was conducted from 1 December 2020 to 1 June 2021 [...]
Categories: I-RECOVER Post-Vaccine
Tags: COVID-19, Melatonin, Sepsis, Thrombosis
This study aimed to determine the effect of melatonin on thrombosis, sepsis, and mortality rate in adult patients with severe coronavirus infection (COVID-19).
Categories: I-CARE Early Covid, MATH+
Tags: COVID-19, Melatonin, Sepsis, Thrombosis
Authors: Barbash IJ, Davis BS, Yabes JG, Seymour CW, Angus DC, Kahn JM PMID: 33872042 PMCID: PMC8844885 DOI: 10.7326/M20-5043 Abstract Background: Medicare requires that hospitals report on their adherence to the Severe Sepsis and Septic Shock Early Management Bundle (SEP-1). Objective: To evaluate the effect of SEP-1 on treatment patterns and patient outcomes. Design: Longitudinal [...]
Categories: I-RECOVER Post-Vaccine
Tags: Sepsis
Authors: Karimi A, Naeini F, Azar VA, Hasanzadeh M. PMID: 33940332 DOI: 10.1016/j.phymed.2021.153567 Abstract Background: Sepsis is a life-threatening condition caused by a dysregulated host response to infection. Several studies have indicated that flavonoids exhibit a wide variety of biological actions including free radical scavenging and antioxidant activities. Quercetin, one of the most extensively distributed [...]
Categories: I-PREVENT, I-RECOVER Post-Vaccine
Authors: Sweeney TE, Liesenfeld O, Wacker J, He YD, rawling D, Remmel M PMID: 33201004 DOI: 10.1097/CCM.0000000000004786 AbstractObjectives: Complex critical syndromes like sepsis and coronavirus disease 2019 may be composed of underling "endotypes," which may respond differently to treatment. The aim of this study was to test whether a previously defined bacterial sepsis endotypes classifier [...]
Categories: MATH+
Authors: Lankadeva YR, Peiris RM, Okazaki N, Birchall IE, Doenom A, Evans RG et al. PMID: 33239507 PMCID: PMC7803449 DOI: 10.1097/CCM.0000000000004770 Abstract Objectives: Oxidative stress appears to initiate organ failure in sepsis, justifying treatment with antioxidants such as vitamin C at megadoses. We have therefore investigated the safety and efficacy of megadose sodium ascorbate in [...]
Categories: MATH+
Authors: Prescott HC, Girard TD doi:10.1001/jama.2020.14103 Abstract As of July 30, 2020, more than 17 million people worldwide have been diagnosed with coronavirus disease 2019 (COVID-19), and more than 665 000 have died. In many countries, the rate of diagnosis continues to increase; for example, more than 50 000 new cases per day were reported in the [...]
Categories: I-RECOVER Long Covid
Authors: Iglesias J, Vassallo AV, Patel V, Sullivan JB, Cavanaugh J, Elbaga Y PMID: 32194058 DOI: 10.1016/j.chest.2020.02.049 Abstract Background: Sepsis is a major public health burden resulting in 25% to 30% in-hospital mortality and accounting for over 20 billion dollars of US hospital costs. Research question: Does hydrocortisone, ascorbic acid, thiamine (HAT) therapy improve clinical [...]
Categories: MATH+
Tags: Ascorbic Acid, Glucocorticoids, Sepsis, Thiamine
Authors: Colunga Biancatelli RM, Berrill M, Mohammed YH, Marik PE PMID: 32148926 PMCID: PMC7024751 DOI: 10.21037/jtd.2019.12.85 Abstract Sepsis affects 30 million people worldwide, leading to 6 million deaths every year (WHO), and despite decades of research, novel initiatives are drastically needed. According to the current literature, oxidative imbalance and mitochondrial dysfunction are common features of [...]
Categories: I-RECOVER Post-Vaccine