Authors: Zeh HJ, Bahary N, Boone BA, Singh AD, Normolle Dp, Hogg ME PMID: 32156749 PMCID: PMC8086597 DOI: 10.1158/1078-0432.CCR-19-4042 Abstract Purpose: We hypothesized that autophagy inhibition would increase response to chemotherapy in the preoperative setting for patients with pancreatic adenocarcinoma. We performed a randomized controlled trial to assess the autophagy inhibitor hydroxychloroquine in combination with [...]

Authors: Amaravadi RK, Kimmelman AC, Debnath J PMID: 31434711 PMCID: PMC7306856 DOI: 10.1158/2159-8290.CD-19-0292 Abstract Autophagy, a multistep lysosomal degradation pathway that supports nutrient recycling and metabolic adaptation, has been implicated as a process that regulates cancer. Although autophagy induction may limit the development of tumors, evidence in mouse models demonstrates that autophagy inhibition can limit [...]

Authors: Xu R, Ji Z, Xu C, Zhu J PMID: 30431566 PMCID: PMC6257684 doi: 10.1097/MD.0000000000012912 Abstract Background: Autophagy is a mechanism which relies on lysosomes for clearance and recycling of abnormal proteins or organelles. Many studies have demonstrated that the deregulation of autophagy is associated with the development of various diseases including cancer. The use [...]

Authors: Mokhtari RB, Baluch N, Homayouni TS, Kumar S, Yeger H PMID: 28735362 PMCID: PMC5842175 DOI: 10.1007/s12079-017-0401-y Abstract Cancer is a multi-stage process resulting from aberrant signaling pathways driving uncontrolled proliferation of transformed cells. The development and progression of cancer from a premalignant lesion towards a metastatic tumor requires accumulation of mutations in many regulatory [...]

Authors: Mogil RJ, Kaste SC, Ferry RJ, Hudson MM, Howell CR PMID: 26967465 PMCID: PMC4945422 DOI: 10.1001/jamaoncol.2015.6557 Abstract Importance: Bone accrual during youth is critical to establish sufficient strength for lifelong skeletal health. Children with cancer may develop low bone mineral density (BMD) any time before or after diagnosis. Objective: To evaluate the ability of [...]

Authors: Karatas F, Sahin S, sever AR, Altundag K PMID: 27247882 PMCID: PMC4864803 DOI: 10.1186/s40064-016-2216-3 Abstract Endocrine therapy-induced hair loss (ETIHL) associated with aromatase inhibitors and tamoxifen treatment is currently mostly reported but remained an unresolved therapeutic issue in patients with breast cancer (BC) since the number of studies regarding the management is limited in [...]

Authors: Nicolson GL, Rosenblatt S, de Mattos GF, Settineri R, Breeding PC, Ash ME PMID: 32309576 PMCID: PMC6941554 DOI: 10.15190/d.2016.1 Abstract Membrane Lipid Replacement is the use of functional oral supplements containing cell membrane glycerolphospholipids and antioxidants to safely replace damaged membrane lipids that accumulate during aging and in various chronic and acute diseases. Most [...]

Authors: Nowotarski SL, Woster PM, Casero RA PMID: 23432971 PMCID: PMC4027058 DOI: 10.1017/erm.2013.3 Abstract Polyamines are small organic cations that are essential for normal cell growth and development in eukaryotes. Under normal physiological conditions, intracellular polyamine concentrations are tightly regulated through a dynamic network of biosynthetic and catabolic enzymes, and a poorly characterised transport system. [...]

Authors: Nicolson GL, Settineri R DOI: 10.31989/ffhd.v1i4.134 Abstract Background: Cancer-associated fatigue and the chronic adverse effects of cancer therapy can be reduced by Lipid Replacement Therapy (LRT) using membrane phospholipid mixtures given as food supplements. Methods: This is a review of the published literature on LRT and its uses. Results: LRT significantly reduced fatigue in [...]