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Auhtors: Seyfried TN, Arismendi-Morillo G, Mukherjee P, Chinopoulos C PMID: 33251492 PMCID: PMC7677709 DOI: 10.1016/j.isci.2020.101761 Abstract ATP is required for mammalian cells to remain viable and to perform genetically programmed functions. Maintenance of the ΔG'ATP hydrolysis of -56 kJ/mole is the endpoint of both genetic and metabolic processes required for life. Various anomalies in mitochondrial [...]
Categories: Cancer Care
Tags: Cancer
Auhtors: Hope JR Abstract How does a trained physician beat terminal cancer when he, himself, gets it? · The answer will both shock and surprise you, as it is often NOT the same treatment that physicians prescribe for their patients. · Dr.Hope takes you through successful survival stories of doctor after doctor -and he explains [...]
Categories: Cancer Care
Tags: Cancer, COVID-19, Drug Repurposing
Auhtors: Diorio C, Kelly KM, Afungchwi GM, Ladas EJ, Marjerrison S PMID: 32614139 DOI: 10.1002/pbc.28324 Abstract Traditional and complementary medicine (T&CM) strategies are commonly used by pediatric cancer patients. Nutritional approaches to T&CM include bioactive compounds, supplements, and herbs as well as dietary approaches. Pediatric cancer patients and their families commonly request and use nutritional [...]
Categories: Cancer Care
Tags: Cancer
Authors: Zeh HJ, Bahary N, Boone BA, Singh AD, Normolle Dp, Hogg ME PMID: 32156749 PMCID: PMC8086597 DOI: 10.1158/1078-0432.CCR-19-4042 Abstract Purpose: We hypothesized that autophagy inhibition would increase response to chemotherapy in the preoperative setting for patients with pancreatic adenocarcinoma. We performed a randomized controlled trial to assess the autophagy inhibitor hydroxychloroquine in combination with [...]
Categories: I-RECOVER Post-Vaccine
Tags: autophagy, Cancer, Hydroxychloroquine
Auhtors: Han MA, Storman D, Al-Rammahy H, Tang S, Hao Q, Leung G, et al. PMID: 32226046 PMCID: PMC7105118 DOI: 10.1371/journal.pone.0230721 Abstract Background: A number of studies have reported on associations between reproductive factors, such as delivery methods, number of birth and breastfeeding, and incidence of cancer in children, but systematic reviews addressing this issue [...]
Categories: Cancer Care
Tags: Cancer
Auhtors: Law AMK, Valdes-Mora F, Gallego-Ortega D PMID: 32121014 PMCID: PMC7140518 DOI: 10.3390/cells9030561 Abstract The emergence of immunotherapy has been an astounding breakthrough in cancer treatments. In particular, immune checkpoint inhibitors, targeting PD-1 and CTLA-4, have shown remarkable therapeutic outcomes. However, response rates from immunotherapy have been reported to be varied, with some having pronounced [...]
Categories: Cancer Care
Tags: Cancer, Myeloid Cells
Auhtors: Alexandrov LB, Kim J, Haradhvala NJ, Huang MN, Tian Ng AW, Wu Y, et al. PMID: 32025018 PMCID: PMC7054213 DOI: 10.1038/s41586-020-1943-3 Abstract Somatic mutations in cancer genomes are caused by multiple mutational processes, each of which generates a characteristic mutational signature1. Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium2 of [...]
Categories: Cancer Care
Tags: Cancer
Authors: Amaravadi RK, Kimmelman AC, Debnath J PMID: 31434711 PMCID: PMC7306856 DOI: 10.1158/2159-8290.CD-19-0292 Abstract Autophagy, a multistep lysosomal degradation pathway that supports nutrient recycling and metabolic adaptation, has been implicated as a process that regulates cancer. Although autophagy induction may limit the development of tumors, evidence in mouse models demonstrates that autophagy inhibition can limit [...]
Categories: I-RECOVER Post-Vaccine
Auhtors: Chazelas E, Srour B, Desmetz E, Kesse-Guyot E, Julia C, Deschamps V, et al. PMID: 31292122 PMCID: PMC6614796 DOI: 10.1136/bmj.l2408 Abstract Objective: To assess the associations between the consumption of sugary drinks (such as sugar sweetened beverages and 100% fruit juices), artificially sweetened beverages, and the risk of cancer. Design: Population based prospective cohort [...]
Categories: Cancer Care
Tags: Cancer, Processed Foods
Auhtors: Ohue Y, Nishikawa H PMID: 31102428 PMCID: PMC6609813 DOI: 10.1111/cas.14069 Abstract Regulatory T (Treg) cells suppress abnormal/excessive immune responses to self- and nonself-antigens to maintain immune homeostasis. In tumor immunity, Treg cells are involved in tumor development and progression by inhibiting antitumor immunity. There are several Treg cell immune suppressive mechanisms: inhibition of costimulatory [...]
Categories: Cancer Care
Tags: Cancer, T Regulatory Cells