Authors: Iglesias J, Vassallo AV, Patel V, Sullivan JB, Cavanaugh J, Elbaga Y PMID: 32194058 DOI: 10.1016/j.chest.2020.02.049 Abstract Background: Sepsis is a major public health burden resulting in 25% to 30% in-hospital mortality and accounting for over 20 billion dollars of US hospital costs. Research question: Does hydrocortisone, ascorbic acid, thiamine (HAT) therapy improve clinical [...]

Authors: Marik PE PMID: 30441816 doi: 10.3390/nu10111762 Abstract Sepsis is a devastating disease that carries an enormous toll in terms of human suffering and lives lost. Over 100 novel pharmacologic agents that targeted specific molecules or pathways have failed to improve the outcome of sepsis. Preliminary data suggests that the combination of Hydrocortisone, Ascorbic Acid [...]

Authors: Marik PE, Khangoora V, Rivera R, Hooper MH, Catravas J PMID: 27940189 DOI: 10.1016/j.chest.2016.11.036 Abstract Background: The global burden of sepsis is estimated as 15 to 19 million cases annually, with a mortality rate approaching 60% in low-income countries. Methods: In this retrospective before-after clinical study, we compared the outcome and clinical course of [...]