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Auhtors: Fong D, Christensen CT, Chan MM PMID: 33563159 DOI: 10.2174/1574892816666210208232251 Abstract Background: Cancer is a multistep process involving genetic and epigenetic changes in the somatic genome. Genetic mutations as well as environmental factors lead to the initiation, promotion, and progression of cancer. Metastasis allows cancer cells to spread via circulatory and lymphatic systems; secondary [...]
Categories: Cancer Care
Auhtors: Dionisio MR, Vieira AF, Carvalho R, Conde I, Oliveira M, Gomes M, et al. PMID: 33182375 PMCID: PMC7695320 DOI: 10.3390/cells9112442 Abstract Brain metastases remain an unmet clinical need in breast oncology, being frequently found in HER2-overexpressing and triple-negative carcinomas. These tumors were reported to be highly cancer stem-like cell-enriched, suggesting that brain metastases probably [...]
Categories: Cancer Care
Tags: Breast Cancer, Cancer Stem Cells
Auhtors: Gorodetska I, Kozeretska I, Dubrovska A PMID: 31205572 PMCID: PMC6548160 DOI: 10.7150/jca.30410 Abstract Carcinogenesis is a multistep process, and tumors frequently harbor multiple mutations regulating genome integrity, cell division and death. The integrity of cellular genome is closely controlled by the mechanisms of DNA damage signaling and DNA repair. The association of breast cancer [...]
Categories: Cancer Care
Tags: Cancer Stem Cells
Auhtors: Dominguez-Gomez G, Chavez-Blanco A, Medina-Franco JL, Saldivar-Gonzalez F, Flores-Torrontegui Y, Juarez M, et al. PMID: 29257278 DOI: 10.3892/mmr.2017.8231 Abstract The aim of the present study was to demonstrate that ivermectin preferentially inhibited cancer stem‑like cells (CSC) in breast cancer cells and downregulated the expression of 'stemness' genes. Computational searching of DrugBank, a database of [...]
Categories: Cancer Care
Tags: Cancer Stem Cells, ivermectin
Auhtors: Singh VK, Saini A, Chandra R PMID: 28785557 PMCID: PMC5520001 DOI: 10.3389/fmolb.2017.00052 Abstract Cancer stem cells (CSCs) are believed to exhibit distinctive self-renewal, proliferation, and differentiation capabilities, and thus play a significant role in various aspects of cancer. CSCs have significant impacts on the progression of tumors, drug resistance, recurrence and metastasis in different [...]
Categories: Cancer Care
Tags: Cancer Stem Cells
Auhtors: Huang Z, Wu T, Liu AY, Ouyang G PMID: 26474460 PMCID: PMC4741845 DOI: 10.18632/oncotarget.6098 Abstract Tumor cells actively contribute to constructing their own microenvironment during tumorigenesis and tumor progression. The tumor microenvironment contains multiple types of stromal cells that work together with the extracellular matrix and local and systemic factors to coordinately contribute to [...]
Categories: Cancer Care
Tags: Cancer Stem Cells
Auhtors: Kurtova AV, Xiao J, Mo Q, Pazhanisamy S, Krasnow R, Lerner SP, et al. PMID: 25470039 PMCID: PMC4465385 DOI: 10.1038/nature14034 Abstract Cytotoxic chemotherapy is effective in debulking tumour masses initially; however, in some patients tumours become progressively unresponsive after multiple treatment cycles. Previous studies have demonstrated that cancer stem cells (CSCs) are selectively enriched [...]
Categories: Cancer Care
Tags: Cancer Stem Cells