The MATH+ Hospital Treatment Protocol for Covid-19 is a physiologic-based combination treatment regimen developed by leaders in critical care medicine. All component medicines are FDA-approved, inexpensive, readily available and have been used for decades with well-established safety profiles.

As a group of colleagues with over 200 years of combined experience in Critical Care and Emergency Medicine, as well as long-standing shared interests in developing effective treatments for critical illnesses including sepsis, we formed a working group devoted to creating a treatment protocol against COVID-19. The protocol we devised, called “MATH+” is intended for use in the hospitalized patient, with an emphasis on early initiation — as soon as the patient develops a need for supplemental oxygen.

In the hospitals that have adopted the protocol and initiated it early in the treatment of patients, both state and medical center data reporting the mortality of COVID-19 patients treated in these hospitals compares strongly with COVID-19 mortality rates published in studies from around the world. Although these data are in evolution, the MATH+ hospitals have been reporting hospital mortality between 4% and 10% (as of July 2020) while the hospital mortality from published reports in the US, Italy, and China average approximately 23%.

August 18, 2020 – published on ‘Taylor & Francis Online’!
MATH+ Protocol for the Treatment of SARS-CoV-2 Infection: The Scientific Rationale [PDF]
Paul E. Marik, Pierre Kory, Joseph Varon, Jose Iglesias & G. Umberto Meduri (FLCCC)

Further information

We have published our MATH+ Treatment Protocol on our download page in several languages. For a detailed explanation of the efficacy of the Protocol please read our Scientific Review of COVID-19 and MATH+. On our page The Research Challenge we explain how the protocol was developed and why we could not ethically conduct placebo-based RCTs. More information about the FLCCC doctors can be found on the FLCCC Physicians page.

Dr. Joseph Varon (FLCCC Alliance) visits a patient during rounds in his COVID-19 unit at United Memorial Medical Center, Houston, TX, USA. July 6, 2020.
Photo: © 2020 David J. Phillip – AP/PA