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References

Categories

I-CARE Early Covid (187) I-CARE Flu and RSV (36) I-PREVENT (153) I-RECOVER Long Covid (111) I-RECOVER Post-Vaccine (320) MATH+ (171)

Tags

ACE2 protein (10) acute respiratory distress syndrome (13) Alopecia (7) Anti-inflammatory (8) Antidepressants (9) Ascorbic Acid (9) autoantibodies (10) autophagy (24) Calcifediol (6) Cancer (9) Corticosteroids (8) COVID-19 (255) COVID-19 Vaccines (8) Curcumin (8) Cytokines (10) Depression (10) Famotidine (14) flavonoids (5) Glucocorticoids (6) Hydroxychloroquine (12) Hyperbaric Oxygen Therapy (9) Inflammation (14) ivermectin (46) long COVID (21) Mast Cells (8) Melatonin (20) molnupiravir (5) N-Acetylcysteine (6) Non-Invasive Brain Stimulation (8) Omicron (7) Oxytocin (8) Pneumonia (8) quercetin (15) resveratrol (5) SARS-CoV-2 (72) SARS-CoV-2 mRNA Vaccines (7) Sepsis (15) spermidine (11) Spike Protein (10) Thrombosis (9) Tinnitus (12) Valproic Acid (5) Vitamin C (16) Vitamin D (9) Zinc (12)
  • Reference: The effects of vitamin C on the multiple pathological stages of COVID-19

    Published On: December 3, 2021

    Jorge R Miranda-Massari, Alondra P Toro, Doris Loh, Jose R Rodriguez, Raul Morales Borges, Victor Marcial-Vega, Jose Olalde, Miguel J Berdiel, Neil H Riordan, Juan Manuel Martinez, Armando Gil, Michael J Gonzalez PMID: 34947872 PMCID: PMC8708699 DOI: 10.3390/life11121341 AbstractCurrently available anti-viral drugs may be useful in reducing the viral load but are not providing the [...]

    Categories: I-PREVENT

    Tags: Ascorbic Acid, COVID-19, SARS-CoV-2

  • Reference: Hydrocortisone, Ascorbic Acid and Thiamine (HAT therapy) for the treatment of sepsis. Focus on ascorbic acid.

    Published On: November 14, 2018

    Authors: Marik PE PMID: 30441816 doi: 10.3390/nu10111762 Abstract Sepsis is a devastating disease that carries an enormous toll in terms of human suffering and lives lost. Over 100 novel pharmacologic agents that targeted specific molecules or pathways have failed to improve the outcome of sepsis. Preliminary data suggests that the combination of Hydrocortisone, Ascorbic Acid [...]

    Categories: I-PREVENT, I-RECOVER Post-Vaccine, MATH+

    Tags: Ascorbic Acid, Hydrocortisone, Sepsis, Thiamine

  • Reference: Hydrocortisone and Ascorbic Acid synergistically protect and repair lipopolysaccharide-induced pulmonary endothelial barrier dysfunction.

    Published On: July 21, 2017

    Authors: Barabutis N, Khangoora V, Marik PE, Catravas JD PMID: 28739448 PMCID: PMC5812759 DOI: 10.1016/j.chest.2017.07.014 Abstract Background: Sepsis refers to the dysregulated host immune response elicited by microbial infections resulting in life-threatening organ dysfunction. Sepsis represents a medical challenge, since it is associated with a rate of death as high as 60%. Septic shock is [...]

    Categories: MATH+

    Tags: Ascorbic Acid, Hydrocortisone

  • Reference: The risk of taking ascorbic acid.

    Published On: March 11, 2013

    Authors: Fletcher RH doi:10.1001/jamainternmed.2013.2305 Abstract Vitamin deficiency diseases, such as pellagra, rickets, beriberi, night blindness, and scurvy, used to account for an enormous burden of suffering worldwide. One by one, the underlying dietary deficiencies were defined, and, in the early part of the 20th century, the chemical structures of the missing nutrients were identified. While [...]

    Categories: I-RECOVER Long Covid

    Tags: Ascorbic Acid

  • Reference: Ascorbic acid prevents oxidant-induced increases in endothelial permeability

    Published On: January 31, 2011

    Oxidative stress acutely increases the permeability of the vascular endothelium to large molecules that would not otherwise cross the barrier. Ascorbic acid is an antioxidant that tightens the endothelial permeability barrier, so we tested whether it might also prevent the increase in endothelial permeability due to cellular oxidative stress.

    Categories: MATH+

    Tags: Ascorbic Acid, Dithiothreitol, Endothelial Permeability, Tempol

  • Reference: Ascorbic acid prevents oxidant-induced increases in endothelial permeability.

    Published On: December 2, 2010

    Authors: May JM, Qu ZC PMID: 21328627 PMCID: PMC3725122 DOI: 10.1002/biof.134 Abstract Oxidative stress acutely increases the permeability of the vascular endothelium to large molecules that would not otherwise cross the barrier. Ascorbic acid is an antioxidant that tightens the endothelial permeability barrier, so we tested whether it might also prevent the increase in endothelial [...]

    Categories: MATH+

    Tags: Ascorbic Acid

  • Reference: Ascorbic acid stimulates barrier function of cultured endothelial cell monolayer

    Published On: May 1, 1995

    The macromolecular permeability of cultured bovine aortic, bovine venous, and human umbilical vein endothelial cell monolayers was decreased significantly in culture medium containing L-ascorbic acid (Asc Acid; 0.01-0.1 mM) and L-ascorbic acid 2-phosphate (Asc 2-P). Dithiothreitol, which shows reducing activity equivalent to that of Asc Acid, did not affect endothelial permeability. Asc Acid induced a sixfold increase in collagen synthesis by the endothelial cells. The coexistence of L-azetidine 2-carboxylic acid, an inhibitor of collagen synthesis, attenuated the effect of Asc 2-P in a dose-dependent manner. Another collagen synthesis inhibitor, ethyl-3,4-dihydroxybenzoate, also inhibited collagen synthesis and increased endothelial permeability. The decrease in permeability of the endothelial monolayer was dependent on a reduction of the permeability coefficient of the endothelial monolayer. These findings indicate that endothelial barrier function is stimulated by Asc Acid via an increase in collagen synthesis.

    Categories: I-RECOVER Post-Vaccine

    Tags: Ascorbic Acid, Collagen

  • Reference: Ascorbic acid stimulates barrier function of cultured endothelial cell monolayer.

    Published On: May 1, 1995

    Authors: Utoguchi N, Ikeda K, Saeki K, Oka N, Mizuguchi H, Kubo K et al. PMID: 7706381 DOI: 10.1002/jcp.1041630219 Abstract The macromolecular permeability of cultured bovine aortic, bovine venous, and human umbilical vein endothelial cell monolayers was decreased significantly in culture medium containing L-ascorbic acid (Asc Acid; 0.01-0.1 mM) and L-ascorbic acid 2-phosphate (Asc 2-P). [...]

    Categories: MATH+

    Tags: Ascorbic Acid

  • Reference: Acute oxalate nephropathy after massive ascorbic acid administration.

    Published On: May 1, 1985

    Authors: Lawton JM, Conway LT, Crosson JT, Smith CL, Abraham PA PMID: 3994472 Abstract A single 45-g dose of intravenous ascorbic acid, a metabolic precursor of oxalate, was administered to a patient as adjuvant therapy for primary amyloidosis and the nephrotic syndrome. Acute oliguric renal failure occurred. Postmortem histopathologic examination of renal tissue revealed extensive [...]

    Categories: I-RECOVER Long Covid

    Tags: Ascorbic Acid, oxalate nephropathy

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