Authors: Ma WH, Zhang XG, Guo LL, Zhang JB, Wei FT PMID: 34109585 DOI: 10.26355/eurrev_202105_25944 Abstract Objective: Experimental autoimmune myocarditis (EAM) is characterized by pronounced macrophage infiltration, cardiac necrosis, and cardiac fibrosis. Our previous studies have demonstrated that suppressed androgen receptor (AR) enables anti-inflammation to promote tissue repair by decreasing M1 macrophages and increasing M2 [...]

Authors: Li G, Wu Z, Shang J, Xie Z, Chen C, Zhang C PMID: 33524789 DOI: 10.1016/j.biopha.2021.111286 Abstract Metformin is the first-line option for treating newly diagnosed diabetic patients and also involved in other pharmacological actions, including antitumor effect, anti-aging effect, polycystic ovarian syndrome prevention, cardiovascular action, and neuroprotective effect, etc. However, the mechanisms of [...]

Authors: Mostafa DK, Khedr MM, Barakat MK, Abdellatif AA, Elsharkawy AM PMID: 33275985 DOI: 10.1016/j.lfs.2020.118818 Abstract Aim: Proton pump inhibitors (PPIs) are widely used drugs recently linked to chronic kidney disease. However, the invloved mechanisms remained elusive. Since defective autophagy is identified as a new culprit in the pathogenesis of diabetic nephropathy (DN), we aimed [...]

Authors: Ghosh I, Sankhe R, Mudgal J, Arora D, Nampoothiri M PMID: 32873420 DOI: 10.1016/j.npep.2020.102083 Abstract Spermidine is a naturally occurring endogenous polyamine synthesized from diamine putrescine. It is a well-known autophagy inducer that maintains cellular and neuronal homeostasis. Healthy brain development and function are dependent on brain polyamine concentration. Polyamines interact with the opioid [...]

Authors: Hannan A, Rahman A, Rahman S, Sohag AA, Dash R, Uddin J. PMID: 32659267 PMCID: PMC7351063 DOI: 10.1016/j.imlet.2020.07.001 Abstract Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative pathogen of deadly Coronavirus disease-19 (COVID-19) pandemic, which emerged as a major threat to public health across the world. Although there is no clear gender or [...]

Authors: Zeh HJ, Bahary N, Boone BA, Singh AD, Normolle Dp, Hogg ME PMID: 32156749 PMCID: PMC8086597 DOI: 10.1158/1078-0432.CCR-19-4042 Abstract Purpose: We hypothesized that autophagy inhibition would increase response to chemotherapy in the preoperative setting for patients with pancreatic adenocarcinoma. We performed a randomized controlled trial to assess the autophagy inhibitor hydroxychloroquine in combination with [...]

Coronavirus disease 19 (COVID-19) is a viral disease caused by the new coronavirus SARS-CoV-2. Like other coronaviral infections, SARS-CoV-2 causes oxidative and ER stress triggering cellular response pathways, mainly PERK and IRE1 branches of the UPR.

Authors: Bharath LP, Agrawal M, McCambridge G, Nichols DA, Hasturk H, Liu J et al. PMID: 32402267 PMCID: PMC7217133 DOI: 10.1016/j.cmet.2020.04.015 Abstract Age is a non-modifiable risk factor for the inflammation that underlies age-associated diseases; thus, anti-inflammaging drugs hold promise for increasing health span. Cytokine profiling and bioinformatic analyses showed that Th17 cytokine production differentiates [...]

Authors: Gassen NC, Papies J, Bajaj T, Emanuel J, Wechmann K, Heinz DE et al. doi: https://doi.org/10.1101/2020.04.15.997254 Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses an acute threat to public health and the world economy, especially because no approved specific drugs or vaccines are available. Pharmacological modulation of metabolism-dependent cellular pathways such as autophagy [...]

Authors: Xu TT, Li H, Dai Z, Lau GK, Li BY, Zhu WL et al. PMID: 32268299 PMCID: PMC7185103 DOI: 10.18632/aging.103035 Abstract The natural polyamine spermidine and spermine have been reported to ameliorate aging and aging-induced dementia. However, the mechanism is still confused. An aging model, the senescence accelerated mouse-8 (SAMP8), was used in this [...]