Categories
Tags
Authors: Liu J, Liang H, Chen C, Wang X, Qu F, Wang H PMID: 31755894 PMCID: PMC6900471 DOI: 10.1042/BSR20192489 Abstract Glioma is one of the most common types of primary brain tumors. Ivermectin (IVM), a broad-spectrum antiparasitic drug, has been identified as a novel anticancer agent due to its inhibitory effects on the proliferation of [...]
Categories: I-RECOVER Post-Vaccine
Tags: autophagy, ivermectin
Authors: Amaravadi RK, Kimmelman AC, Debnath J PMID: 31434711 PMCID: PMC7306856 DOI: 10.1158/2159-8290.CD-19-0292 Abstract Autophagy, a multistep lysosomal degradation pathway that supports nutrient recycling and metabolic adaptation, has been implicated as a process that regulates cancer. Although autophagy induction may limit the development of tumors, evidence in mouse models demonstrates that autophagy inhibition can limit [...]
Categories: I-RECOVER Post-Vaccine
Authors: Morishita H, Mizushima N PMID: 31283377 DOI: 10.1146/annurev-cellbio-100818-125300 Abstract Macroautophagy is an intracellular degradation system that delivers diverse cytoplasmic materials to lysosomes via autophagosomes. Recent advances have enabled identification of several selective autophagy substrates and receptors, greatly expanding our understanding of the cellular functions of autophagy. In this review, we describe the diverse cellular [...]
Categories: I-RECOVER Post-Vaccine
Tags: autophagy
Authors: Xu R, Ji Z, Xu C, Zhu J PMID: 30431566 PMCID: PMC6257684 doi: 10.1097/MD.0000000000012912 Abstract Background: Autophagy is a mechanism which relies on lysosomes for clearance and recycling of abnormal proteins or organelles. Many studies have demonstrated that the deregulation of autophagy is associated with the development of various diseases including cancer. The use [...]
Categories: I-RECOVER Post-Vaccine
Tags: autophagy, Cancer, Hydroxychloroquine
Authors: Kou X, Chen N PMID: 28837083 PMCID: PMC5622687 DOI: 10.3390/nu9090927 Abstract Alzheimer's disease (AD) is one of the most common neurodegenerative disorders over the age of 65 years old. Although several underlying mechanisms for explaining the pathogenesis of AD are elucidated, the effective supplements or drugs for the intervention of AD are still limited. [...]
Categories: I-RECOVER Long Covid, I-RECOVER Post-Vaccine
Tags: alzheimers, autophagy, resveratrol
Authors: Park D, Jeong H, Lee MN, Koh A, Kwon O, Yang YR et al. PMID: 26902888 PMCID: PMC4763238 DOI: 10.1038/srep21772 Abstract Resveratrol (RSV) is a natural polyphenol that has a beneficial effect on health, and resveratrol-induced autophagy has been suggested to be a key process in mediating many beneficial effects of resveratrol, such as [...]
Categories: I-RECOVER Long Covid, I-RECOVER Post-Vaccine
Tags: autophagy, resveratrol
Authors: Wolpin BM, Rubinson DA, Wang X, Chan JA, Cleary JM, Enzinger PC et al. PMID: 24821822 PMCID: PMC4041680 DOI: 10.1634/theoncologist.2014-0086 Abstract Background: Autophagy is a catabolic pathway that permits cells to recycle intracellular macromolecules, and its inhibition reduces pancreatic cancer growth in model systems. We evaluated hydoxychloroquine (HCQ), an inhibitor of autophagy, in patients [...]
Categories: I-RECOVER Post-Vaccine
Tags: autophagy, Hydroxychloroquine
Authors: Pietrocola F, Malik SA, Marino G, Vacchelli E, Senovilla L, Chaba K et al. PMID: 24769862 PMCID: PMC4111762 DOI: 10.4161/cc.28929 Abstract Epidemiological studies and clinical trials revealed that chronic consumption coffee is associated with the inhibition of several metabolic diseases as well as reduction in overall and cause-specific mortality. We show that both natural [...]
Categories: I-RECOVER Post-Vaccine
Tags: autophagy
Authors: Sinha RA, Farah BL, Singh BK, Siddique MM, Li Y, Wu Y et al. PMID: 23929677 DOI: 10.1002/hep.26667 Abstract Caffeine is one of the world's most consumed drugs. Recently, several studies showed that its consumption is associated with lower risk for nonalcoholic fatty liver disease (NAFLD), an obesity-related condition that recently has become the [...]
Categories: I-RECOVER Post-Vaccine
Authors: Ray K PMID: 23982685 DOI: 10.1038/nrgastro.2013.170 Abstract Coffee drinking is a global phenomenon, with an estimated >2.25 billion cups of coffee consumed in the world every day. A myriad of health benefits across a wide range of diseases have been attributed to coffee consumption and much research has focussed on the effects of caffeine [...]
Categories: I-RECOVER Post-Vaccine