Caffeine is a potent stimulator of autophagy to reduce hepatic lipid content – a coffee for NAFLD?
Published On: August 27, 2013|
Authors: Ray K
PMID: 23982685 DOI: 10.1038/nrgastro.2013.170
Coffee drinking is a global phenomenon, with an estimated >2.25 billion cups of coffee consumed in the world every day. A myriad of health benefits across a wide range of diseases have been attributed to coffee consumption and much research has focussed on the effects of caffeine on the liver. Now, a new study published in Hepatology has investigated the mechanism of action of caffeine on lipid metabolism, finding that caffeine reduces lipid content in the liver via the autophagy–lysosomal pathway.