Authors: Swank Z, Senussi Y, Alter G, Walt DR PMID: 36052466 PMCID: PMC10169416 DOI: 10.1093/cid/ciac722 Abstract The diagnosis of postacute sequelae of coronavirus disease 2019 (PASC) poses an ongoing medical challenge. To identify biomarkers associated with PASC we analyzed plasma samples collected from PASC and coronavirus disease 2019 patients to quantify viral antigens and inflammatory [...]

Authors: Lee MJ, Leong MW, Rustagi A, Beck A, Zeng L, Holmes S PMID: 36543165 PMCID: PMC9742201 DOI: 10.1016/j.celrep.2022.111892 Abstract Natural killer (NK) cells are cytotoxic effector cells that target and lyse virally infected cells; many viruses therefore encode mechanisms to escape such NK cell killing. Here, we interrogate the ability of SARS-CoV-2 to modulate [...]

Authors: Nunez-Castilla J, Stebliankin V, Baral P, Balbin CA, Sobhan M, Cickovski T et al. PMID: 35891400 PMCID: PMC9318917 DOI: 10.3390/v14071415 Abstract Molecular mimicry between viral antigens and host proteins can produce cross-reacting antibodies leading to autoimmunity. The coronavirus SARS-CoV-2 causes COVID-19, a disease curiously resulting in varied symptoms and outcomes, ranging from asymptomatic to [...]

Authors: Gallardo-Zapata J, Maldonado-Bernal C PMID: 35733383 PMCID: PMC9389049 DOI: 10.1177/17534259221077750 Abstract At the end of 2019, an outbreak of a severe respiratory disease occurred in Wuhan China, and an increase in cases of unknown pneumonia was alerted. In January 2020, a new coronavirus named SARS-CoV-2 was identified as the cause. The virus spreads primarily [...]

Authors: Nystrom S, Hammarstrom P PMID: 35579205 PMCID: PMC9136918 DOI: 10.1021/jacs.2c03925 Abstract SARS-CoV-2 infection is associated with a surprising number of morbidities. Uncanny similarities with amyloid-disease associated blood coagulation and fibrinolytic disturbances together with neurologic and cardiac problems led us to investigate the amyloidogenicity of the SARS-CoV-2 spike protein (S-protein). Amyloid fibril assays of peptide [...]

Authors: Gupta K, Strymish J, Stack G, Chamess M DOI: https://doi.org/10.21203/rs.3.rs-1588371/v1 Abstract Initiation of NM/R treatment on Day 0 in a 71-year-old vaccinated and boosted male resulted in rapid resolution of COVID-19 symptoms followed one week later by the development of typical cold symptoms. SARS-CoV-2 viral load fluctuated in parallel with symptoms, with two distinct [...]

The Omicron SARS-CoV-2 variant is responsible for a major wave of COVID-19, with record case counts reflecting high transmissibility and escape from prior immunity. Defining the time course of Omicron viral proliferation and clearance is crucial to inform isolation protocols aiming to minimize disease spread.

Authors: Roltgen K, Nielsen SC, Silva O, Younes SF, Yang F, Wirz OF PMID: 35148837 PMCID: PMC8786601 DOI: 10.1016/j.cell.2022.01.018 Abstract During the SARS-CoV-2 pandemic, novel and traditional vaccine strategies have been deployed globally. We investigated whether antibodies stimulated by mRNA vaccination (BNT162b2), including third-dose boosting, differ from those generated by infection or adenoviral (ChAdOx1-S and [...]

The SARS-CoV-2 B.1.1.529 (Omicron) variant contains 15 mutations of the receptor-binding domain (RBD). How Omicron evades RBD-targeted neutralizing antibodies requires immediate investigation.

Authors: Molina-Carballo A, Palacios-Lopez R, Jerez-Calero A, Agil A PMID: 35723382 PMCID: PMC8929125 DOI: 10.3390/cimb44010003 Abstract according to the World Health Organization (WHO), COVID-19 is an infectious disease caused by the SARS-CoV-2 virus, responsible for an increasing number of cases and deaths. From a preventive and therapeutic point of view, there are two concerns that [...]