Auhtors: Mortezaee K, Majidpoor J
PMID: 35432340 PMCID: PMC9010719 DOI: 10.3389/fimmu.2022.864298
Abstract
Dysregulated innate and adaptive immunity is a sign of SARS-CoV-2-induced disease and cancer. CD8+ T cells are important cells of the immune system. The cells belong to the adaptive immunity and take a front-line defense against viral infections and cancer. Extreme CD8+ T-cell activities in the lung of patients with a SARS-CoV-2-induced disease and within the tumor microenvironment (TME) will change their functionality into exhausted state and undergo apoptosis. Such diminished immunity will put cancer cases at a high-risk group for SARS-CoV-2-induced disease, rendering viral sepsis and a more severe condition which will finally cause a higher rate of mortality. Recovering responses from CD8+ T cells is a purpose of vaccination against SARS-CoV-2. The aim of this review is to discuss the CD8+ T cellular state in SARS-CoV-2-induced disease and in cancer and to present some strategies for recovering the functionality of these critical cells.
Keywords: CD8+ T cell; SARS-CoV-2; cancer; exhaustion; hypoxia; immune checkpoint inhibitor (ICI); memory T cell; programmed death 1 receptor (PD-1).
Source: https://pubmed.ncbi.nlm.nih.gov/35432340/
Archive: https://archive.is/x9mqs
