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FLCCC | Front Line COVID-19 Critical Care Alliance
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References

Categories

I-CARE Early Covid (3) I-CARE Flu and RSV (1) I-PREVENT (28) I-RECOVER Long Covid (3) I-RECOVER Post-Vaccine (3) MATH+ (20)

Tags

25-hydroxyvitamin D (2) 25‐HYDROXY VITAMIN D (2) Ambulatory treatment (2) Anti-inflammatory (2) Anti-Inflammatory Agents (1) Anticoagulant (2) Antimicrobial Cationic Peptides (1) Antiparasitic Agents (3) Antiviral (2) Ascorbic Acid (3) Calcifediol (1) Collagen (1) Coronavirus (2) COVID-19 (23) Dithiothreitol (1) Endothelial Barrier (1) Endothelial Permeability (1) Epidemiology (2) Ergocalciferols (1) Famotidine (7) Fixed drug eruption (1) Glucocorticosteroids (3) Heparanase (2) Human immunodeficiency virus (HIV) (1) Hydroxychloroquine (2) Inflammation (4) ivermectin (18) Melatonin (13) Methylprednisol (2) Nitric Oxide (1) Omicron (6) Onchocerciasis (1) pharmacokinetics (1) Pneumonia (2) SARS-CoV-2 (20) Sars-CoV2 (2) Sepsis (3) Septic (2) Spike Protein (5) Stevens–Johnson syndrome (SJS) (1) Tempol (1) viral infection (3) Vitamin C (3) Vitamin D (6) vitamin D 2 (1)
  • Reference: Viral dynamics and duration of PCR positivity of the SARS-CoV-2 Omicron variant

    Published On: April 5, 2022

    The Omicron SARS-CoV-2 variant is responsible for a major wave of COVID-19, with record case counts reflecting high transmissibility and escape from prior immunity. Defining the time course of Omicron viral proliferation and clearance is crucial to inform isolation protocols aiming to minimize disease spread.

    Categories:

    Tags: COVID-19, Omicron, SARS-CoV-2, viral infection

  • Reference: Vaccine effectiveness against SARS-CoV-2 infection with the Omicron or Delta variants following a two-dose or booster BNT162b2 or mRNA-1273 vaccination series: A danish cohort study

    Published On: December 22, 2021

    In this brief communication we are showing original research results with early estimates from Danish nationwide databases of vaccine effectiveness (VE) against the novel SARS-CoV-2 Omicron variant (B.1.1.529) up to five months after a primary vaccination series with the BNT162b2 or mRNA-1273 vaccines. Our study provides evidence of protection against infection with the Omicron variant after completion of a primary vaccination series with the BNT162b2 or mRNA-1273 vaccines; in particular, we found a VE against the Omicron variant of 55.2% (95% confidence interval (CI): 23.5 to 73.7%) and 36.7% (95% CI: 69.9 to 76.4%) for the BNT162b2 and mRNA-1273 vaccines, respectively, in the first month after primary vaccination. However, the VE is significantly lower than that against Delta infection and declines rapidly over just a few months. The VE is re-established upon revaccination with the BNT162b2 vaccine (54.6%, 95% CI: 30.4 to 70.4%).

    Categories:

    Tags: BNT162b2, COVID-19, Delta, mRNA-1273, Omicron

  • Reference: Epidemiological characterization of the first 785 SARS-CoV-2 Omicron variant cases in Denmark, December 2021

    Published On: December 16, 2021

    By 9 December 2021, 785 SARS-CoV-2 Omicron variant cases have been identified in Denmark. Most cases were fully (76%) or booster-vaccinated (7.1%); 34 (4.3%) had a previous SARS-CoV-2 infection. The majority of cases with available information reported symptoms (509/666; 76%) and most were infected in Denmark (588/644; 91%).

    Categories:

    Tags: COVID-19, Denmark, Epidemiology, Omicron, SARS-CoV-2

  • Reference: SARS-CoV-2 Omicron variant: Characteristics and prevention

    Published On: December 16, 2021

    Characteristics and treatment of Omicron variant of COVID-19.

    Categories:

    Tags: COVID-19, Omicron, SARS-CoV-2

  • Reference: The omicron variant is highly resistant against antibody-mediated neutralization- implications for control of the COVID-19 pandemic

    Published On: December 13, 2021

    The rapid spread of the SARS-CoV-2 Omicron variant suggests that the virus might become globally dominant. Further, the high number of mutations in the viral spike-protein raised concerns that the virus might evade antibodies induced by infection or vaccination. Here, we report that the Omicron spike was resistant against most therapeutic antibodies but remained susceptible to inhibition by Sotrovimab.

    Categories:

    Tags: COVID-19, Omicron

  • Reference: The effects of vitamin C on the multiple pathological stages of COVID-19

    Published On: December 3, 2021

    Jorge R Miranda-Massari, Alondra P Toro, Doris Loh, Jose R Rodriguez, Raul Morales Borges, Victor Marcial-Vega, Jose Olalde, Miguel J Berdiel, Neil H Riordan, Juan Manuel Martinez, Armando Gil, Michael J Gonzalez PMID: 34947872 PMCID: PMC8708699 DOI: 10.3390/life11121341 AbstractCurrently available anti-viral drugs may be useful in reducing the viral load but are not providing the [...]

    Categories: I-PREVENT

    Tags: Ascorbic Acid, COVID-19, SARS-CoV-2

  • Reference: Vitamin C intervention for Critical COVID-19: A pragmatic review of the current level of evidence

    Published On: November 1, 2021

    Severe respiratory infections are characterized by elevated inflammation and generation of reactive oxygen species (ROS) which may lead to a decrease in antioxidants such as vitamin C and a higher requirement for the vitamin.

    Categories: I-PREVENT

    Tags: acute respiratory distress syndrome, clinical trials, COVID-19, Sars-CoV2, Sepsis, Vitamin C

  • Reference: The effect of melatonin on thrombosis, sepsis and mortality rate in COVID-19 patients

    Published On: October 12, 2021

    This study aimed to determine the effect of melatonin on thrombosis, sepsis, and mortality rate in adult patients with severe coronavirus infection (COVID-19).

    Categories: MATH+

    Tags: COVID-19, Melatonin, Sepsis, Thrombosis

  • Reference: Review of the emerging evidence demonstrating the efficacy of ivermectin in the prophylaxis and treatment of COVID-19

    Published On: June 28, 2021

    After COVID-19 emerged on U.S shores, providers began reviewing the emerging basic science, translational, and clinical data to identify potentially effective treatment options. In addition, a multitude of both novel and repurposed therapeutic agents were used empirically and studied within clinical trials.

    Categories:

    Tags: COVID-19, ivermectin, pulmonary infection, respiratory failure

  • Reference: Review of the emerging evidence supporting the use of Ivermectin in the prophylaxis and treatment of COVID-19

    Published On: April 22, 2021

    After COVID-19 emerged on U.S shores, providers began reviewing the emerging basic science, translational, and clinical data to identify potentially effective treatment options. In addition, a multitude of both novel and repurposed therapeutic agents were used empirically and studied within clinical trials.

    Categories: I-PREVENT

    Tags: COVID-19, ivermectin

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