Authors: Prescott HC, Girard TD
doi:10.1001/jama.2020.14103
Abstract
As of July 30, 2020, more than 17 million people worldwide have been diagnosed with coronavirus disease 2019 (COVID-19), and more than 665 000 have died. In many countries, the rate of diagnosis continues to increase; for example, more than 50 000 new cases per day were reported in the US during the last week of July.
Patients with severe disease, which affects up to 20% of those hospitalized with COVID-19, develop viral sepsis and acute respiratory distress syndrome (ARDS). While there has been substantial focus on the potentially unique manifestations of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), many of the acute manifestations and outcomes of severe COVID-19 are similar to those of sepsis caused by other pathogens.
Approximately 80% of patients hospitalized with COVID-19, and 60% of those admitted to intensive care units (ICUs), survive. However, similar to the experiences of other sepsis survivors,1 many COVID-19 survivors are likely to experience long-lasting morbidity.
Keywords: COVID-19, SARS-CoV-2, recover, sepsis
