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References

Categories

I-CARE Early Covid (187) I-CARE Flu and RSV (36) I-PREVENT (153) I-RECOVER Long Covid (111) I-RECOVER Post-Vaccine (320) MATH+ (198)

Tags

ACE2 protein (10) acute respiratory distress syndrome (14) Alopecia (7) Anti-inflammatory (9) Antidepressants (9) Ascorbic Acid (12) autoantibodies (10) autophagy (24) Calcifediol (6) Cancer (9) Corticosteroids (9) COVID-19 (270) COVID-19 Vaccines (8) Curcumin (8) Cytokines (12) Depression (10) Famotidine (14) flavonoids (5) Glucocorticoids (7) Hydroxychloroquine (12) Hyperbaric Oxygen Therapy (9) Inflammation (14) ivermectin (47) long COVID (21) Mast Cells (8) Melatonin (20) Methylprednisolone (7) molnupiravir (5) N-Acetylcysteine (6) Non-Invasive Brain Stimulation (8) Omicron (7) Oxytocin (8) Pneumonia (8) quercetin (15) SARS-CoV-2 (72) SARS-CoV-2 mRNA Vaccines (7) Sepsis (18) spermidine (11) Spike Protein (10) Thiamine (7) Thrombosis (9) Tinnitus (12) Vitamin C (28) Vitamin D (10) Zinc (12)
  • Reference: Inhibitions of SARS-CoV 3CL protease by flavonoids.

    Published On: December 3, 2020

    Authors: Jo S, Kim S, Shin DH, Kim MS. PMID: 31724441 PMCID: PMC6882434 DOI: 10.1080/14756366.2019.1690480 Abstract There were severe panics caused by Severe Acute Respiratory Syndrome (SARS) and Middle-East Respiratory Syndrome-Coronavirus. Therefore, researches targeting these viruses have been required. Coronaviruses (CoVs) have been rising targets of some flavonoids. The antiviral activity of some flavonoids against [...]

    Categories: I-CARE Early Covid, I-PREVENT, I-RECOVER Post-Vaccine

    Tags: flavonoids

  • Reference: The roles of flavonols/flavonoids in neurodegeneration and neuroinflammation.

    Published On: June 27, 2020

    Authors: Calis Z, Mogulkoc R, Baltaci AK. PMID: 31288717 DOI: 10.2174/1389557519666190617150051 Abstract The inflammatory process in the human body is a physiological response involving many cellular types and mediators. It results in scar formation to separate the damaged area from the surrounding healthy tissue. Because of increased blood-brain barrier permeability following inflammation, leukocytes infiltrate the [...]

    Categories: I-CARE Early Covid, I-CARE Flu and RSV, I-PREVENT, I-RECOVER Long Covid, I-RECOVER Post-Vaccine

    Tags: flavonoids, Neuroinflammation

  • Reference: Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19)

    Published On: June 19, 2020

    Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) represents an emergent global threat which is straining worldwide healthcare capacity. As of May 27th, the disease caused by SARS-CoV-2 (COVID-19) has resulted in more than 340,000 deaths worldwide, with 100,000 deaths in the US alone. It is imperative to study and develop pharmacological treatments suitable for the prevention and treatment of COVID-19. Ascorbic acid is a crucial vitamin necessary for the correct functioning of the immune system. It plays a role in stress response and has shown promising results when administered to the critically ill. Quercetin is a well-known flavonoid whose antiviral properties have been investigated in numerous studies. There is evidence that vitamin C and quercetin co-administration exerts a synergistic antiviral action due to overlapping antiviral and immunomodulatory properties and the capacity of ascorbate to recycle quercetin, increasing its efficacy. Safe, cheap interventions which have a sound biological rationale should be prioritized for experimental use in the current context of a global health pandemic. We present the current evidence for the use of vitamin C and quercetin both for prophylaxis in high-risk populations and for the treatment of COVID-19 patients as an adjunct to promising pharmacological agents such as Remdesivir or convalescent plasma.

    Categories: I-PREVENT

    Tags: flavonoids, quercetin, SARS-CoV-2, Vitamin C

  • Reference: Flavonoids as cytokine modulators: A possible therapy for inflammation-related diseases.

    Published On: June 9, 2016

    Authors: Leyva-Lopez N, Gutierrez-Grijalva EP, Ambriz-Perez D. PMID: PMC4926454 DOI: 10.3390/ijms17060921 Abstract High levels of cytokines, such as interleukin (IL)-1β, tumor necrosis factor (TNF)-α and IL-6, are associated with chronic diseases like rheumatoid arthritis, asthma, atherosclerosis, Alzheimer's disease and cancer; therefore cytokine inhibition might be an important target for the treatment of these diseases. Most [...]

    Categories: I-CARE Early Covid, I-CARE Flu and RSV, I-PREVENT, I-RECOVER Post-Vaccine

    Tags: Cytokines, flavonoids

  • Reference: Flavonoid combinations cause synergistic inhibition of proinflammatory mediator secretion form lipopolysaccharide-induced RAW 264.7 cells.

    Published On: March 11, 2010

    Authors: Harasstaini OA, Moin S, Tham CL, Liew CY, Ismail N, Israf DA PMID: 20221843 DOI: 10.1007/s00011-010-0182-8 Abstract Objectives: We evaluated several flavonoid combinations for synergy in the inhibition of proinflammatory mediator synthesis in the RAW 264.7 cellular model of inflammation. Methods: The inhibitory effect of chrysin, kaempferol, morin, silibinin, quercetin, diosmin and hesperidin upon [...]

    Categories: I-RECOVER Post-Vaccine

    Tags: flavonoids

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