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Auhtors: D'Errico G, Alonso-Nocelo M, Vallespinos M, Hermann PC, Alcalá S, GarcÃa CP, et al. PMID: 30936462 DOI: 10.1038/s41388-019-0803-9 Abstract Pancreatic ductal adenocarcinoma (PDAC) is an inherently chemoresistant tumor. Chemotherapy leads to apoptosis of cancer cells, and in previous studies we have shown that tumor-associated macrophage (TAM) infiltration increases following chemotherapy in PDAC. Since one [...]
Categories: Cancer Care
Tags: Macrophages, Pancreatic Cancer, Tumor
Auhtors: Shukla SK, Gebregiworgis T, Purohit V, Chaika NV, Gunda V, Radhakrishnan P, et al. PMID: 25228990 PMCID: PMC4165433 DOI: 10.1186/2049-3002-2-18 Abstract Background: Aberrant energy metabolism is a hallmark of cancer. To fulfill the increased energy requirements, tumor cells secrete cytokines/factors inducing muscle and fat degradation in cancer patients, a condition known as cancer cachexia. [...]
Categories: Cancer Care
Tags: Ketone Bodies, Pancreatic Cancer
Auhtors: Ino Y, Yamazaki-Itoh R, Shimada K, Iwasaki M, Kosuge T, Kanai Y, Hiraoka N PMID: 23385730 PMCID: PMC3590668 DOI: 10.1038/bjc.2013.32 Abstract Background: The host immune reaction is represented by immune/inflammatory cell infiltrates. Here we systematically analysed tumour-infiltrating immune/inflammatory cells in pancreatic ductal carcinoma (PDC) and evaluated their clinicopathological impact. Methods: Using immunohistochemistry, we examined [...]
Categories: Cancer Care
Tags: Pancreatic Cancer