Auhtors: Sun P, Wang H, He Z, Chen X, Wu Q, Chen W, et al. PMID: 29088814 PMCID: PMC5650369 DOI: 10.18632/oncotarget.20301 Abstract Dietary restriction has been recognized as a healthy and natural therapy for cancer. It is reported that different forms of dietary restriction can promote anti-tumor immunity. However, it is not clear how fasting [...]

Authors: Fung J, Moore J Abstract Thousands of books have been written about the latest and greatest diets that will help people lose weight and improve health. But a key element in any successful nutritional health program is a tried-and-true method that most people haven’t thought about—yet it could be revolutionary for taking health to [...]

Auhtors: Marinac CR, Nelson SH, Breen CI, Hartman SJ, Natarajan L, Pierce JP, et al. PMID: 27032109 PMCID: PMC4982776 DOI: 10.1001/jamaoncol.2016.0164 Abstract Importance: Rodent studies demonstrate that prolonged fasting during the sleep phase positively influences carcinogenesis and metabolic processes that are putatively associated with risk and prognosis of breast cancer. To our knowledge, no studies [...]

Authors: Hine C, Mitchell JR PMID: 24905161 PMCID: PMC4278638 DOI: 10.1016/j.stem.2014.05.016 Abstract Aging and chemotherapeutics damage hematopoietic stem cells (HSCs), leading to dysregulation of asymmetric division and subsequent immunosuppression and blood-related diseases. In this issue, Cheng et al. (2014) use prolonged fasting as a medical intervention to decrease IGF-1/PKA signaling and protect HSCs against chemotherapeutic [...]

Authors: Cheng CW, Adams GB, Perin L, Wei M, Zhou X, Lam BS PMID: 24905167 PMCID: PMC4102383 DOI: 10.1016/j.stem.2014.04.014 Abstract Immune system defects are at the center of aging and a range of diseases. Here, we show that prolonged fasting reduces circulating IGF-1 levels and PKA activity in various cell populations, leading to signal [...]

Auhtors: Cheng CW, Adams GB, Perin L, Wei M, Zhou X, Lam BS. PMID: 24905167 PMCID: PMC4102383 DOI: 10.1016/j.stem.2014.04.014 Abstract Immune system defects are at the center of aging and a range of diseases. Here, we show that prolonged fasting reduces circulating IGF-1 levels and PKA activity in various cell populations, leading to signal transduction [...]

Auhtors: Lee C, Raffaghello L, Brandhorst S, Safdie FM, Bianchi G, Pistoria V, Wei M. PMID: 22323820 PMCID: PMC3608686 DOI: 10.1126/scitranslmed.3003293 Abstract Short-term starvation (or fasting) protects normal cells, mice, and potentially humans from the harmful side effects of a variety of chemotherapy drugs. Here, we show that treatment with starvation conditions sensitized yeast cells [...]