Authors: Hine C, Mitchell JR

PMID: 24905161 PMCID: PMC4278638 DOI: 10.1016/j.stem.2014.05.016


Aging and chemotherapeutics damage hematopoietic stem cells (HSCs), leading to dysregulation of asymmetric division and subsequent immunosuppression and blood-related diseases. In this issue, Cheng et al. (2014) use prolonged fasting as a medical intervention to decrease IGF-1/PKA signaling and protect HSCs against chemotherapeutic toxicity and promote rejuvenation.

Keywords: fasting, chemotherapy, hematopoietic stem cells, IGF-1/PKA