Authors: Fung J, Moore J Abstract Thousands of books have been written about the latest and greatest diets that will help people lose weight and improve health. But a key element in any successful nutritional health program is a tried-and-true method that most people haven’t thought about—yet it could be revolutionary for taking health to [...]

Authors: Hine C, Mitchell JR PMID: 24905161 PMCID: PMC4278638 DOI: 10.1016/j.stem.2014.05.016 Abstract Aging and chemotherapeutics damage hematopoietic stem cells (HSCs), leading to dysregulation of asymmetric division and subsequent immunosuppression and blood-related diseases. In this issue, Cheng et al. (2014) use prolonged fasting as a medical intervention to decrease IGF-1/PKA signaling and protect HSCs against chemotherapeutic [...]

Authors: Cheng CW, Adams GB, Perin L, Wei M, Zhou X, Lam BS PMID: 24905167 PMCID: PMC4102383 DOI: 10.1016/j.stem.2014.04.014 Abstract Immune system defects are at the center of aging and a range of diseases. Here, we show that prolonged fasting reduces circulating IGF-1 levels and PKA activity in various cell populations, leading to signal [...]