Auhtors: Jo SB, Sung SJ, Choi HS, Park J-S, Hong Y-K, Joe YA PMID: 36305295 PMCID: PMC9622313 DOI: 10.4062/biomolther.2022.122 Abstract Mebendazole (MBZ), a microtubule depolymerizing drug commonly used for the treatment of helminthic infections, has been suggested as a repositioning candidate for the treatment of brain tumors. However, the efficacy of MBZ needs further study [...]

Auhtors: Li J, Fan Y, Zhang Y, Liu Y, Yu Y, Ma M PMID: 35745143 PMCID: PMC9228598 DOI: 10.3390/nu14122413 Abstract Resveratrol (RSV) has been reported to induce autophagy and apoptosis in non-small-cell lung cancer A549 cells, and the nerve growth factor receptor (NGFR) regulates autophagy and apoptosis in many other cells. However, the effect of [...]

Authors: Ma WH, Zhang XG, Guo LL, Zhang JB, Wei FT PMID: 34109585 DOI: 10.26355/eurrev_202105_25944 Abstract Objective: Experimental autoimmune myocarditis (EAM) is characterized by pronounced macrophage infiltration, cardiac necrosis, and cardiac fibrosis. Our previous studies have demonstrated that suppressed androgen receptor (AR) enables anti-inflammation to promote tissue repair by decreasing M1 macrophages and increasing M2 [...]

Auhtors: Mengual D, Medrano LE, Villamizar-Villamizar W, Osorio-Llanes E, Mendoza-Torres E, Bolívar S PMID: 35745567 PMCID: PMC9228383 DOI: 10.3390/ph15060648 Abstract Cancer is one of the main causes of death globally. Most of the molecular mechanisms underlying cancer are marked by complex aberrations that activate the critical cell-signaling pathways that play a pivotal role in cell [...]

Auhtors: Ming H, Li B, Tian H, Zhou L, Jian J, Zhang T, et al. PMID: 35634171 PMCID: PMC9130112 DOI: 10.1016/j.mtbio.2022.100289 Abstract Previously used in anti-fungal therapy, itraconazole has now been shown to be successful in treating advanced breast cancer (NCT00798135). However, its poor solubility still restricts its application in clinical treatment. There is therefore [...]

Auhtors: Wang Y, Lu X, Wang X, Qiu Q, Zhu P, Ma L, et al. PMID: 34384247 PMCID: PMC8484060 DOI: 10.1161/CIRCRESAHA.121.319104 Abstract Rationale: Anthracycline-induced cardiotoxicity (AIC) is a major side effect that limits the use of anthracyclines as effective chemotherapeutics. No mechanism-based therapy is available when cardiac function deteriorates. Objective: We aim to elucidate the [...]

Auhtors: Gorabi AM, Kiaie N, Aslani S, Sathyapalan T, Jamialahmadi T, Sahebkar A PMID: 34373771 PMCID: PMC8349293 DOI: 10.1155/2021/9599608 Abstract Statins, which are functionally known as 3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) inhibitors, are lipid-lowering compounds widely prescribed in patients with cardiovascular diseases (CVD). Several biological and therapeutic functions have been attributed to statins, including neuroprotection, antioxidation, anti-inflammation, and [...]

Authors: Li G, Wu Z, Shang J, Xie Z, Chen C, Zhang C PMID: 33524789 DOI: 10.1016/j.biopha.2021.111286 Abstract Metformin is the first-line option for treating newly diagnosed diabetic patients and also involved in other pharmacological actions, including antitumor effect, anti-aging effect, polycystic ovarian syndrome prevention, cardiovascular action, and neuroprotective effect, etc. However, the mechanisms of [...]

Authors: Mostafa DK, Khedr MM, Barakat MK, Abdellatif AA, Elsharkawy AM PMID: 33275985 DOI: 10.1016/j.lfs.2020.118818 Abstract Aim: Proton pump inhibitors (PPIs) are widely used drugs recently linked to chronic kidney disease. However, the invloved mechanisms remained elusive. Since defective autophagy is identified as a new culprit in the pathogenesis of diabetic nephropathy (DN), we aimed [...]

Authors: Ghosh I, Sankhe R, Mudgal J, Arora D, Nampoothiri M PMID: 32873420 DOI: 10.1016/j.npep.2020.102083 Abstract Spermidine is a naturally occurring endogenous polyamine synthesized from diamine putrescine. It is a well-known autophagy inducer that maintains cellular and neuronal homeostasis. Healthy brain development and function are dependent on brain polyamine concentration. Polyamines interact with the opioid [...]