Auhtors: Wang T, Dong Y, Huang Z, Zhang G, Zhao Y, Yao H, et al. PMID: 37651203 PMCID: PMC10575724 DOI: 10.1172/JCI169671 Abstract Lung cancer progression relies on angiogenesis, which is a response to hypoxia typically coordinated by hypoxia-inducible transcription factors (HIFs), but growing evidence indicates that transcriptional programs beyond HIFs control tumor angiogenesis. Here, we [...]

Auhtors: Mukherjee P, Greenwood B, Henao J, Kiebish MA, Seyfried TN doi: https://doi.org/10.1101/2023.06.09.544252 Abstract Invasion of high-grade glioma (HGG) cells through the brain and spinal cord is a leading cause of cancer death in children. Despite advances in treatment, survivors often suffer from life-long adverse effects of the toxic therapies. This study investigated the influence [...]

Auhtors: Wimalawansa SJ PMID: 37371637 PMCID: PMC10295227 DOI: 10.3390/biomedicines11061542 Abstract Vitamin D is essential for life-its sufficiency improves metabolism, hormonal release, immune functions, and maintaining health. Vitamin D deficiency increases the vulnerability and severity of type 2 diabetes, metabolic syndrome, cancer, obesity, and infections. The active enzyme that generates vitamin D [calcitriol: 1,25(OH)2D], CYP27B1 (1α-hydoxylase), [...]

Authors: Halma MT, Plothe C, Marik P, Lawrie T PMID: 37317282 PMCID: PMC10222799 DOI: 10.3390/microorganisms11051308 Abstract In the wake of the COVID-19 crisis, a need has arisen to prevent and treat two related conditions, COVID-19 vaccine injury and long COVID-19, both of which can trace at least part of their aetiology to the spike protein, [...]

Auhtors: Cornelius ME, Loretan CG, Jamal A, Davis Lynn BC, Mayer M, Alcantara IC, Neff L Abstract What is already known about this topic? Tobacco product use remains the leading cause of preventable disease and death in the United States. What is added by this report? In 2021, approximately 18.7% (46 million) of U.S. adults [...]

Auhtors: Costanzo M, De Giglio MAR, Roviello GN PMID: 37175509 PMCID: PMC10178366 DOI: 10.3390/ijms24097803 Abstract Some viruses are known to be associated with the onset of specific cancers. These microorganisms, oncogenic viruses or oncoviruses, can convert normal cells into cancer cells by modulating the central metabolic pathways or hampering genomic integrity mechanisms, consequently inhibiting the [...]

Auhtors: Morsi DS, Barnawi IO, Ibrahim HM, El-Morsy AM, El H, El Latif HM PMID: 37080065 DOI: 10.1016/j.intimp.2023.110135 Abstract Sildenafil is a potent phosphodiesterase-5 (PDE5) inhibitor that effectively inhibits cGMP and increases the strength of nitric oxide. PDE5 was overexpressed in several carcinomas, including breast cancer, which inhibited tumor growth and cell division. The current [...]

Auhtors: Alvarez-Jimenez L, Morales-Palomo F, Merno-Cabanas A, Ortega JF, Mora-Rodrigues R PMID: 36965747 DOI: 10.1016/j.ejphar.2023.175672 Abstract Aims: To update the evidence about the diabetogenic effect of statins. Methods: We searched for randomized-controlled trials reporting the effects of statin therapy on glycosylated hemoglobin (HbA1c) and/or homeostatic model insulin resistance (i.e., HOMA-IR) as indexes of diabetes. Studies [...]

Auhtors: Tan X, Cai K, Li J, Yuan Z, Chen R, Xiao H, et al. PMID: 36952345 PMCID: PMC9998290 DOI: 10.1016/j.celrep.2023.112286 Abstract ER-phagy is a form of autophagy that is mediated by ER-phagy receptors and selectively degrades endoplasmic reticulum (ER). Coronaviruses have been shown to use the ER as a membrane source to establish their [...]

Auhtors: Heng Y, Zhu X, Lin H, Jingyu M, Ding X, Tao L, Lu L PMID: 36864443 PMCID: PMC9983170 DOI: 10.1186/s12967-023-03910-4 Abstract Background: Tumor-associated macrophages (TAMs) are major component in the tumor microenvironment (TME) and play regulatory role in tumor progression. We aimed to investigate the infiltration and prognostic value of TAMs in laryngeal squamous [...]