Authors: Patidar GK, Land KJ, Vrielink H, Dann EJ, Spitalnik SL PMID: 33730761 PMCID: PMC8250601 DOI: 10.1111/vox.13067 Abstract Background and objectives: Cytokine release syndrome in COVID-19 is due to a pathological inflammatory response of raised cytokines. Removal of these cytokines by therapeutic plasma exchange (TPE) prior to end-organ damage may improve clinical outcomes. This manuscript [...]

Authors: Fernandez J, Gratacos-Gines J, Olivas P, Costa M, Nieto S, Mateo D PMID: 32833695 PMCID: PMC7493773 DOI: 10.1097/CCM.0000000000004613 Abstract Objectives: Infection by severe acute respiratory syndrome coronavirus-2 can induce uncontrolled systemic inflammation and multiple organ failure. The aim of this study was to evaluate if plasma exchange, through the removal of circulating mediators, can [...]

Authors: Keith P, Wells AH, Hodges J, Fast SH PMID: 32831133 PMCID: PMC7443810 DOI: 10.1186/s13054-020-03241-6 Abstract Background: Sepsis remains a common condition with high mortality when multiple organ failure develops. The evidence for therapeutic plasma exchange (TPE) in this setting is promising but inconclusive. Our study aims to evaluate the efficacy of adjunct TPE for [...]

Authors: Gucyetmez B, Atalan HK, Sertdemir I, Cakir U, Telci L PMID: 32771054 PMCID: PMC7414262 DOI: 10.1186/s13054-020-03215-8 Abstract In patients with COVID-19 pneumonia, high risk of thrombosis became a current issue, and D-dimer levels indicating fibrin degradation products (FDPs) in the plasma were found as a predictor for mortality. Although unfractionated heparin (UFH) and low-molecular-weight [...]

Authors: Morath C, Weigand MA, Zeier M, Speer C, Tiwari-Heckler S PMID: 32753056 PMCID: PMC7399583 DOI: 10.1186/s13054-020-03171-3 Abstract The spectrum of coronavirus disease 2019 (COVID-19) ranges from asymptomatic infection to respiratory failure and death of patients. Severely affected patients may develop a cytokine storm-like clinical syndrome with multi-organ failure and a mortality rate of up [...]

Authors: Khamis F, Al-Zakwani I, Al Hashmi S, Al Dowaiki S, Al Bahrani M PMID: 32585284 PMCID: PMC7308750 DOI: 10.1016/j.ijid.2020.06.064 Abstract Objective: To evaluate the therapeutic use of plasma exchange in COVID-19 patients compared to controls. Methods: A case series of critically ill adult men and non-pregnant women, ≥18 years of age, with laboratory-confirmed COVID-19, [...]

Authors: Keith P, Day M, Perkins L, Moyer L, Hewitt K, Wells A PMID: 32241301 PMCID: PMC7117947 DOI: 10.1186/s13054-020-2836-4 Abstract The novel coronavirus (“SARS-CoV-2”) outbreak has created a sense of panic globally and has the medical community rapidly searching for answers. An estimated 100,000 individuals have already been infected with nearly 3300 deaths attributed to [...]