Authors: Patidar GK, Land KJ, Vrielink H, Dann EJ, Spitalnik SL PMID: 33730761 PMCID: PMC8250601 DOI: 10.1111/vox.13067 Abstract Background and objectives: Cytokine release syndrome in COVID-19 is due to a pathological inflammatory response of raised cytokines. Removal of these cytokines by therapeutic plasma exchange (TPE) prior to end-organ damage may improve clinical outcomes. This manuscript [...]

Authors: Fernandez J, Gratacos-Gines J, Olivas P, Costa M, Nieto S, Mateo D PMID: 32833695 PMCID: PMC7493773 DOI: 10.1097/CCM.0000000000004613 Abstract Objectives: Infection by severe acute respiratory syndrome coronavirus-2 can induce uncontrolled systemic inflammation and multiple organ failure. The aim of this study was to evaluate if plasma exchange, through the removal of circulating mediators, can [...]

Authors: Gucyetmez B, Atalan HK, Sertdemir I, Cakir U, Telci L PMID: 32771054 PMCID: PMC7414262 DOI: 10.1186/s13054-020-03215-8 Abstract In patients with COVID-19 pneumonia, high risk of thrombosis became a current issue, and D-dimer levels indicating fibrin degradation products (FDPs) in the plasma were found as a predictor for mortality. Although unfractionated heparin (UFH) and low-molecular-weight [...]

Authors: Morath C, Weigand MA, Zeier M, Speer C, Tiwari-Heckler S PMID: 32753056 PMCID: PMC7399583 DOI: 10.1186/s13054-020-03171-3 Abstract The spectrum of coronavirus disease 2019 (COVID-19) ranges from asymptomatic infection to respiratory failure and death of patients. Severely affected patients may develop a cytokine storm-like clinical syndrome with multi-organ failure and a mortality rate of up [...]

Authors: Keith P, Day M, Perkins L, Moyer L, Hewitt K, Wells A PMID: 32241301 PMCID: PMC7117947 DOI: 10.1186/s13054-020-2836-4 Abstract The novel coronavirus (“SARS-CoV-2”) outbreak has created a sense of panic globally and has the medical community rapidly searching for answers. An estimated 100,000 individuals have already been infected with nearly 3300 deaths attributed to [...]