Auhtors: Wimalawansa SJ PMID: 35889955 PMCID: PMC9319502 DOI: 10.3390/nu14142997 Abstract Vitamin D deficiency is a global public health problem, a pandemic that commonly affects the elderly and those with comorbidities such as obesity, diabetes, hypertension, respiratory disorders, recurrent infections, immune deficiency, and malignancies, as well as ethnic minorities living in temperate countries. The same groups [...]

Severe respiratory infections are characterized by elevated inflammation and generation of reactive oxygen species (ROS) which may lead to a decrease in antioxidants such as vitamin C and a higher requirement for the vitamin.

Authors: Hasan ZT, AlAtrakji MQ, Mehuaiden AK PMID: 34653660 PMCID: PMC8506572 DOI: 10.1016/j.ijid.2021.10.012 Abstract Objectives: This study aimed to determine the effect of melatonin on thrombosis, sepsis, and mortality rate in adult patients with severe coronavirus infection (COVID-19). Methods: This single-center, prospective, randomized clinical trial was conducted from 1 December 2020 to 1 June 2021 [...]

This study aimed to determine the effect of melatonin on thrombosis, sepsis, and mortality rate in adult patients with severe coronavirus infection (COVID-19).

Authors: Barbash IJ, Davis BS, Yabes JG, Seymour CW, Angus DC, Kahn JM PMID: 33872042 PMCID: PMC8844885 DOI: 10.7326/M20-5043 Abstract Background: Medicare requires that hospitals report on their adherence to the Severe Sepsis and Septic Shock Early Management Bundle (SEP-1). Objective: To evaluate the effect of SEP-1 on treatment patterns and patient outcomes. Design: Longitudinal [...]

Authors: Karimi A, Naeini F, Azar VA, Hasanzadeh M. PMID: 33940332 DOI: 10.1016/j.phymed.2021.153567 Abstract Background: Sepsis is a life-threatening condition caused by a dysregulated host response to infection. Several studies have indicated that flavonoids exhibit a wide variety of biological actions including free radical scavenging and antioxidant activities. Quercetin, one of the most extensively distributed [...]

Authors: Sweeney TE, Liesenfeld O, Wacker J, He YD, rawling D, Remmel M PMID: 33201004 DOI: 10.1097/CCM.0000000000004786 AbstractObjectives: Complex critical syndromes like sepsis and coronavirus disease 2019 may be composed of underling "endotypes," which may respond differently to treatment. The aim of this study was to test whether a previously defined bacterial sepsis endotypes classifier [...]

Authors: Lankadeva YR, Peiris RM, Okazaki N, Birchall IE, Doenom A, Evans RG et al. PMID: 33239507 PMCID: PMC7803449 DOI: 10.1097/CCM.0000000000004770 Abstract Objectives: Oxidative stress appears to initiate organ failure in sepsis, justifying treatment with antioxidants such as vitamin C at megadoses. We have therefore investigated the safety and efficacy of megadose sodium ascorbate in [...]

Authors: Prescott HC, Girard TD doi:10.1001/jama.2020.14103 Abstract As of July 30, 2020, more than 17 million people worldwide have been diagnosed with coronavirus disease 2019 (COVID-19), and more than 665 000 have died. In many countries, the rate of diagnosis continues to increase; for example, more than 50 000 new cases per day were reported in the [...]

Authors: Iglesias J, Vassallo AV, Patel V, Sullivan JB, Cavanaugh J, Elbaga Y PMID: 32194058 DOI: 10.1016/j.chest.2020.02.049 Abstract Background: Sepsis is a major public health burden resulting in 25% to 30% in-hospital mortality and accounting for over 20 billion dollars of US hospital costs. Research question: Does hydrocortisone, ascorbic acid, thiamine (HAT) therapy improve clinical [...]