Auhtors: Zeh HJ, Bahary N, Boone BA, Singh AD, Normolle Dp, Hogg ME PMID: 32156749 PMCID: PMC8086597 DOI: 10.1158/1078-0432.CCR-19-4042 Abstract Purpose: We hypothesized that autophagy inhibition would increase response to chemotherapy in the preoperative setting for patients with pancreatic adenocarcinoma. We performed a randomized controlled trial to assess the autophagy inhibitor hydroxychloroquine in combination with [...]

Auhtors: D'Errico G, Alonso-Nocelo M, Vallespinos M, Hermann PC, Alcalá S, García CP, et al. PMID: 30936462 DOI: 10.1038/s41388-019-0803-9 Abstract Pancreatic ductal adenocarcinoma (PDAC) is an inherently chemoresistant tumor. Chemotherapy leads to apoptosis of cancer cells, and in previous studies we have shown that tumor-associated macrophage (TAM) infiltration increases following chemotherapy in PDAC. Since one [...]

Auhtors: Zhu Y, Bu S PMID: 29081818 PMCID: PMC5610853 DOI: 10.1155/2017/5787218 Abstract Objective: Curcumin is an active extract from turmeric. The aim of this study was to identify the underlying mechanism of curcumin on PCa cells and the role of autophagy in this process. Methods: The inhibitory effect of curcumin on the growth of PANC1 [...]

Auhtors: Shukla SK, Gebregiworgis T, Purohit V, Chaika NV, Gunda V, Radhakrishnan P, et al. PMID: 25228990 PMCID: PMC4165433 DOI: 10.1186/2049-3002-2-18 Abstract Background: Aberrant energy metabolism is a hallmark of cancer. To fulfill the increased energy requirements, tumor cells secrete cytokines/factors inducing muscle and fat degradation in cancer patients, a condition known as cancer cachexia. [...]

Auhtors: Ino Y, Yamazaki-Itoh R, Shimada K, Iwasaki M, Kosuge T, Kanai Y, Hiraoka N PMID: 23385730 PMCID: PMC3590668 DOI: 10.1038/bjc.2013.32 Abstract Background: The host immune reaction is represented by immune/inflammatory cell infiltrates. Here we systematically analysed tumour-infiltrating immune/inflammatory cells in pancreatic ductal carcinoma (PDC) and evaluated their clinicopathological impact. Methods: Using immunohistochemistry, we examined [...]