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Auhtors: D'Agostino DM, Bernardi P, Chieco-Bianchi L, Ciminale V PMID: 16096000 DOI: 10.1016/S0065-230X(05)94003-7 Abstract Molecular analyses of tumor virus-host cell interactions have provided key insights into the genes and pathways involved in neoplastic transformation. Recent studies have revealed that the human tumor viruses Epstein-Barr virus (EBV), Kaposi's sarcoma-associated herpesvirus (KSHV), human papillomavirus (HPV), hepatitis B [...]
Categories: Cancer Care
Auhtors: Guezva JM, Krajewska M, de Heredia ML, Krajewski S, Santamaria G, Kim H, et al. PMID: 12438266 Abstract Mitochondrial H+-ATP synthase is required for cellular energy provision and for efficient execution of apoptosis. Almost one century ago, Otto Warburg proposed the hypothesis that mitochondrial function might be impaired in cancer cells. However, his hypothesis [...]
Categories: Cancer Care
Tags: Cancer, Mitochondria, Tumor
Auhtors: Delsite R, Kachhap S, Anbazhagan R, Gabrielson E, Singh KK PMID: 12495447 PMCID: PMC149409 DOI: 10.1186/1476-4598-1-6 Abstract Background: The interaction of nuclear and mitochondrial genes is an essential feature in maintenance of normal cellular function. Of 82 structural subunits that make up the oxidative phosphorylation system in the mitochondria, mitochondrial DNA (mtDNA) encodes 13 [...]
Categories: Cancer Care
Tags: Cancer, Mitochondria
Auhtors: John AP PMID: 11601863 DOI: 10.1054/mehy.2001.1335 Abstract It has been known for decades that cancer cells produce excessive amounts of lactic acid. The fact that most cancers have poor vascular systems has led cancer scientists to assume that such cells are deprived of a normal supply of oxygen. Researchers believe that without sufficient oxygen, [...]
Categories: Cancer Care
Tags: Cancer, lac, Mitochondria