Auhtors: Shukla SK, Gebregiworgis T, Purohit V, Chaika NV, Gunda V, Radhakrishnan P, et al. PMID: 25228990 PMCID: PMC4165433 DOI: 10.1186/2049-3002-2-18 Abstract Background: Aberrant energy metabolism is a hallmark of cancer. To fulfill the increased energy requirements, tumor cells secrete cytokines/factors inducing muscle and fat degradation in cancer patients, a condition known as cancer cachexia. [...]

Auhtors: Newman JC, Verdin E PMID: 24140022 PMCID: PMC4176946 DOI: 10.1016/j.tem.2013.09.002 Abstract Traditionally, the ketone body β-hydroxybutyrate (βOHB) has been looked upon as a carrier of energy from liver to peripheral tissues during fasting or exercise. However, βOHB also signals via extracellular receptors and acts as an endogenous inhibitor of histone deacetylases (HDACs). These recent [...]