Authors: Ndeupen S, Qin Z, Jacobsen S, Bouteau A, Estanbouli H, Igyarto BZ PMID: 34841223 PMCID: PMC8604799 DOI: 10.1016/j.isci.2021.103479 Abstract Vaccines based on mRNA-containing lipid nanoparticles (LNPs) are a promising new platform used by two leading vaccines against COVID-19. Clinical trials and ongoing vaccinations present with varying degrees of protection levels and side effects. However, [...]

Authors: Shu C, Feng S, Cui Q, Cheng S, Wang Y PMID: 34353036 DOI: 10.21037/apm-21-640 Abstract Background: Previous studies have reported that C reactive protein (CRP), tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6) in Coronavirus disease 2019 (COVID-19) patients are significantly increased, and their progressive increases are clinical warning indicators of severe and critical severity. [...]

Authors: Hamilton D, Jensen GS PMID: 33882028 Abstract Objectives: To evaluate the effects of ATP 360, a nutraceutical energy formula, in people experiencing long-term fatigue affecting daily living. To explore the use of ex vivo mitochondrial stress testing to evaluate cellular energy improvements with nutraceutical support. Study design: An open-label study design was used with [...]

Reports suggest a role of endothelial dysfunction and loss of endothelial barrier function in COVID-19. It is well established that the endothelial glycocalyx-degrading enzyme heparanase contributes to vascular leakage and inflammation.

Konrad Kleszczyński, Andrzej T Slominski, Kerstin Steinbrink, Russel J Reiter PMID: 32847033 PMCID: PMC7551551 DOI: 10.3390/nu12092561 AbstractThe recent pandemic of COVID-19 has already infected millions of individuals and has resulted in the death of hundreds of thousands worldwide. Based on clinical features, pathology, and the pathogenesis of respiratory disorders induced by this and other highly [...]

Authors: Bharath LP, Agrawal M, McCambridge G, Nichols DA, Hasturk H, Liu J et al. PMID: 32402267 PMCID: PMC7217133 DOI: 10.1016/j.cmet.2020.04.015 Abstract Age is a non-modifiable risk factor for the inflammation that underlies age-associated diseases; thus, anti-inflammaging drugs hold promise for increasing health span. Cytokine profiling and bioinformatic analyses showed that Th17 cytokine production differentiates [...]

Authors: Leisman DE, Deutschman CS, Legrand M PMID: 32347323 PMCID: PMC7186535 DOI: 10.1007/s00134-020-06059-6 Abstract Current management guidelines for COVID-19 reflect the assumption that critically ill patients infected with SARS-CoV-2 develop acute respiratory distress syndrome (ARDS). However, emerging data and clinical reports increasingly suggest an alternative view that severe COVID-19 reflects a confluence of vascular dysfunction, [...]

Authors: Tay MZ, Poh CM, Renia L, MacAry PA PMID: 32346093 PMCID: PMC7187672 DOI: 10.1038/s41577-020-0311-8 Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the ongoing coronavirus disease 2019 (COVID-19) pandemic. Alongside investigations into the virology of SARS-CoV-2, understanding the fundamental physiological and immunological processes underlying the clinical manifestations of COVID-19 [...]

Authors: Zhou Y, Fu B, Zheng X, Wang D, Zhao C PMID: 34676125 PMCID: PMC7108005 DOI: 10.1093/nsr/nwaa041 Abstract Pathogenic human coronavirus infections, such as severe acute respiratory syndrome CoV (SARS-CoV) and Middle East respiratory syndrome CoV (MERS-CoV), cause high morbidity and mortality [1,2]. Recently, a severe pneumonia-associated respiratory syndrome caused by a new coronavirus (SARS-CoV-2) [...]

Authors: Falkenberg RI, Eising C, Peters ML PMID: 29429046 DOI: 10.1007/s10865-018-9914-y Abstract Yoga is an ancient mind-body practice that is increasingly recognized to have health benefits in a variety of clinical and non-clinical conditions. This systematic review summarizes the findings of randomized controlled trials examining the effects of yoga on immune system functioning which is [...]