Authors: Leisman DE, Deutschman CS, Legrand M

PMID: 32347323 PMCID: PMC7186535 DOI: 10.1007/s00134-020-06059-6


Current management guidelines for COVID-19 reflect the assumption that critically ill patients infected with SARS-CoV-2 develop acute respiratory distress syndrome (ARDS). However, emerging data and clinical reports increasingly suggest an alternative view that severe COVID-19 reflects a confluence of vascular dysfunction, thrombosis, and dysregulated inflammation.

Keywords: COVID-19, SARS-CoV-2, vascular dysfunction, thrombosis, inflammation, dysregulated inflammation