Auhtors: Cheng CW, Adams GB, Perin L, Wei M, Zhou X, Lam BS. PMID: 24905167 PMCID: PMC4102383 DOI: 10.1016/j.stem.2014.04.014 Abstract Immune system defects are at the center of aging and a range of diseases. Here, we show that prolonged fasting reduces circulating IGF-1 levels and PKA activity in various cell populations, leading to signal transduction [...]