Authors: Ray K PMID: 23982685 DOI: 10.1038/nrgastro.2013.170 Abstract Coffee drinking is a global phenomenon, with an estimated >2.25 billion cups of coffee consumed in the world every day. A myriad of health benefits across a wide range of diseases have been attributed to coffee consumption and much research has focussed on the effects of caffeine [...]

Auhtors: Shin S, Jing K, Jeong S, Kim N, Song K-S, Heo J-Y, et al. PMID: 23841076 PMCID: PMC3691929 DOI: 10.1155/2013/568671 Abstract Docosahexaenoic acid (DHA) induces autophagy-associated apoptotic cell death in wild-type p53 cancer cells via regulation of p53. The present study investigated the effects of DHA on PC3 and DU145 prostate cancer cell lines [...]

Authors: LaRocca TJ, Gioscia-Ryan RA, Hearon CM, Seals DR PMID: 23612189 PMCID: PMC3700669 DOI: 10.1016/j.mad.2013.04.004 Abstract Arterial aging, characterized by stiffening of large elastic arteries and the development of arterial endothelial dysfunction, increases cardiovascular disease (CVD) risk. We tested the hypothesis that spermidine, a nutrient associated with the anti-aging process autophagy, [...]

Authors: Morselli E, Marino G, Bennetzen MV, Eisenberg T, Megalou E, Schroeder S et al. PMID: 21339330 PMCID: PMC3044119 DOI: 10.1083/jcb.201008167 Abstract Autophagy protects organelles, cells, and organisms against several stress conditions. Induction of autophagy by resveratrol requires the nicotinamide adenine dinucleotide-dependent deacetylase sirtuin 1 (SIRT1). In this paper, we show that the acetylase inhibitor [...]

Authors: Morselli E, Galluzzi L, Kepp O, Criollo A, Maiuri MC, Madeo F PMID: 20157579 PMCID: PMC2815753 DOI: 10.18632/aging.100110 Abstract Although autophagy has widely been conceived as a self-destructive mechanism that causes cell death, accumulating evidence suggests that autophagy usually mediates cytoprotection, thereby avoiding the apoptotic or necrotic demise of stressed cells. Recent evidence produced [...]

Authors: Eisenberg T, Knauer H, Schauer A, Buttner S, Carmona-Gutierrez D, Ring J et al. PMID: 19801973 DOI: 10.1038/ncb1975 Abstract Ageing results from complex genetically and epigenetically programmed processes that are elicited in part by noxious or stressful events that cause programmed cell death. Here, we report that administration of spermidine, a natural polyamine whose [...]

Auhtors: Tsukada M, Ohsumi Y PMID: 8224160 DOI: 10.1016/0014-5793(93)80398-e Abstract Autophagy in the yeast is similar to that in mammalian cells. A mutant designated as apg1 (autophagy) defective in accumulation of autophagic bodies in the vacuoles was isolated by selection using a light microscope from a mutagenized proteinase-deficient strain. In the apg1 strain, which has [...]

Auhtors: Takeshige K, Baba M, Tsuboi S, Noda T, Ohsumi Y PMID: 1400575 PMCID: PMC2289660 DOI: 10.1083/jcb.119.2.301 Abstract For determination of the physiological role and mechanism of vacuolar proteolysis in the yeast Saccharomyces cerevisiae, mutant cells lacking proteinase A, B, and carboxypeptidase Y were transferred from a nutrient medium to a synthetic medium devoid of [...]