Auhtors: Xu R, Ji Z, Xu C, Zhu J PMID: 30431566 PMCID: PMC6257684 DOI: 10.1097/MD.0000000000012912 Abstract Background: Autophagy is a mechanism which relies on lysosomes for clearance and recycling of abnormal proteins or organelles. Many studies have demonstrated that the deregulation of autophagy is associated with the development of various diseases including cancer. The use [...]

Auhtors: Zhang Y, Fan Y, Huang S, Wang G, Han R, Lei F, et al. PMID: 30259603 PMCID: PMC6272120 DOI: 10.1111/cas.13808 Abstract Thymoquinone (TQ, 2-methyl-5-isopropyl-1,4-benzoquinone), a bioactive constituent extracted from the seeds of Nigella sativa, has been proved to exert anti-tumor efficiency in various cancers. Autophagy is a self-digestion phenomenon, and its role in tumor [...]

Auhtors: Yu C, Li W-b, Liu J-b, Lu J-w, Feng J-f PMID: 29282893 PMCID: PMC5806108 DOI: 10.1002/cam4.1287 Abstract In eukaryotic cells, autophagy is a process associated with programmed cell death. During this process, cytoplasmic proteins and organelles are engulfed by double-membrane autophagosomes, which then fuse with lysosomes to form autolysosomes. These autolysosomes then degrade their [...]

Auhtors: Zhu Y, Bu S PMID: 29081818 PMCID: PMC5610853 DOI: 10.1155/2017/5787218 Abstract Objective: Curcumin is an active extract from turmeric. The aim of this study was to identify the underlying mechanism of curcumin on PCa cells and the role of autophagy in this process. Methods: The inhibitory effect of curcumin on the growth of PANC1 [...]

Authors: Kou X, Chen N PMID: 28837083 PMCID: PMC5622687 DOI: 10.3390/nu9090927 Abstract Alzheimer's disease (AD) is one of the most common neurodegenerative disorders over the age of 65 years old. Although several underlying mechanisms for explaining the pathogenesis of AD are elucidated, the effective supplements or drugs for the intervention of AD are still limited. [...]

Authors: Park D, Jeong H, Lee MN, Koh A, Kwon O, Yang YR et al. PMID: 26902888 PMCID: PMC4763238 DOI: 10.1038/srep21772 Abstract Resveratrol (RSV) is a natural polyphenol that has a beneficial effect on health, and resveratrol-induced autophagy has been suggested to be a key process in mediating many beneficial effects of resveratrol, such as [...]

Auhtors: Wang J, Nie D DOI: 10.5772/61484 Abstract Fatty acids are important molecules with multiple biological properties. Emerging evidence suggests that fatty acids can modulate autophagy. Saturated fatty acids contribute to pancreatic β-cell dysfunction in type 2 diabetes. Palmitic acid, one of the long-chain saturated fatty acids (LCFA), induces autophagy of β-cells which protects them [...]

Authors: Wolpin BM, Rubinson DA, Wang X, Chan JA, Cleary JM, Enzinger PC et al. PMID: 24821822 PMCID: PMC4041680 DOI: 10.1634/theoncologist.2014-0086 Abstract Background: Autophagy is a catabolic pathway that permits cells to recycle intracellular macromolecules, and its inhibition reduces pancreatic cancer growth in model systems. We evaluated hydoxychloroquine (HCQ), an inhibitor of autophagy, in patients [...]

Authors: Pietrocola F, Malik SA, Marino G, Vacchelli E, Senovilla L, Chaba K et al. PMID: 24769862 PMCID: PMC4111762 DOI: 10.4161/cc.28929 Abstract Epidemiological studies and clinical trials revealed that chronic consumption coffee is associated with the inhibition of several metabolic diseases as well as reduction in overall and cause-specific mortality. We show that both natural [...]

Authors: Sinha RA, Farah BL, Singh BK, Siddique MM, Li Y, Wu Y et al. PMID: 23929677 DOI: 10.1002/hep.26667 Abstract Caffeine is one of the world's most consumed drugs. Recently, several studies showed that its consumption is associated with lower risk for nonalcoholic fatty liver disease (NAFLD), an obesity-related condition that recently has become the [...]