Authors: Liu J, Liang H, Chen C, Wang X, Qu F, Wang H PMID: 31755894 PMCID: PMC6900471 DOI: 10.1042/BSR20192489 Abstract Glioma is one of the most common types of primary brain tumors. Ivermectin (IVM), a broad-spectrum antiparasitic drug, has been identified as a novel anticancer agent due to its inhibitory effects on the proliferation of [...]

Auhtors: Tian Y, Song W, Li D, Cai L, Zhao Y PMID: 31802896 PMCID: PMC6802539 DOI: 10.2147/OTT.S213043 Abstract Resveratrol, as a natural product compound, has been recently attracted much attention for its potent effects on cancer. Cancer is a serious disease threatening human survival and social development. Autophagy is a cellular pathway to realize the [...]

Auhtors: Amaravadi RK, Kimmelman AC, Debnath J PMID: 31434711 PMCID: PMC7306856 DOI: 10.1158/2159-8290.CD-19-0292 Abstract Autophagy, a multistep lysosomal degradation pathway that supports nutrient recycling and metabolic adaptation, has been implicated as a process that regulates cancer. Although autophagy induction may limit the development of tumors, evidence in mouse models demonstrates that autophagy inhibition can limit [...]

Authors: Amaravadi RK, Kimmelman AC, Debnath J PMID: 31434711 PMCID: PMC7306856 DOI: 10.1158/2159-8290.CD-19-0292 Abstract Autophagy, a multistep lysosomal degradation pathway that supports nutrient recycling and metabolic adaptation, has been implicated as a process that regulates cancer. Although autophagy induction may limit the development of tumors, evidence in mouse models demonstrates that autophagy inhibition can limit [...]

Authors: Morishita H, Mizushima N PMID: 31283377 DOI: 10.1146/annurev-cellbio-100818-125300 Abstract Macroautophagy is an intracellular degradation system that delivers diverse cytoplasmic materials to lysosomes via autophagosomes. Recent advances have enabled identification of several selective autophagy substrates and receptors, greatly expanding our understanding of the cellular functions of autophagy. In this review, we describe the diverse cellular [...]

Auhtors: Morishita H, Mizushima N PMID: 31283377 DOI: 10.1146/annurev-cellbio-100818-125300 Abstract Macroautophagy is an intracellular degradation system that delivers diverse cytoplasmic materials to lysosomes via autophagosomes. Recent advances have enabled identification of several selective autophagy substrates and receptors, greatly expanding our understanding of the cellular functions of autophagy. In this review, we describe the diverse cellular [...]

Auhtors: De Santi M, Baldelli G, Diotallevi A, Galluzzi L, Schiavano GF, Brandi G PMID: 30635619 PMCID: PMC6329809 DOI: 10.1038/s41598-018-37247-6 Abstract Autophagy is a cellular mechanism by which cells degrade intracellular components in lysosomes, maintaining cellular homeostasis. It has been hypothesized that autophagy could have a role in cancer prevention through the elimination of damaged [...]

Auhtors: Sung SJ, Kim H-K, Hong Y-K, Joe YA PMID: 30642153 PMCID: PMC6319545 DOI: 10.4062/biomolther.2018.222 Abstract Mebendazole (MBZ), a microtubule depolymerizing drug commonly used for the treatment of helminthic infections, has recently been noted as a repositioning candidate for angiogenesis inhibition and cancer therapy. However, the definite anti-angiogenic mechanism of MBZ remains unclear. In this [...]

Auhtors: Antures F, Erustes AG, Costa AJ, Nascimento AC, Bincoletto C, Ureshino RP, Smali SS PMID: 30540126 PMCID: PMC6257056 DOI: 10.6061/clinics/2018/e814s Abstract Cancer is a leading cause of death worldwide, and its incidence is continually increasing. Although anticancer therapy has improved significantly, it still has limited efficacy for tumor eradication and is highly toxic to [...]

Authors: Xu R, Ji Z, Xu C, Zhu J PMID: 30431566 PMCID: PMC6257684 doi: 10.1097/MD.0000000000012912 Abstract Background: Autophagy is a mechanism which relies on lysosomes for clearance and recycling of abnormal proteins or organelles. Many studies have demonstrated that the deregulation of autophagy is associated with the development of various diseases including cancer. The use [...]