Authors: Riche F PMID: 29467023 PMCID: PMC5822646 DOI: 10.1186/s13054-017-1934-4 Abstract Background: Sepsis is a leading cause of mortality and critical illness worldwide and is associated with an increased mortality rate in the months following hospital discharge. The occurrence of persistent or new organ dysfunction(s) after septic shock raises questions about the mechanisms involved in the [...]

Authors: Kou X, Chen N PMID: 28837083 PMCID: PMC5622687 DOI: 10.3390/nu9090927 Abstract Alzheimer's disease (AD) is one of the most common neurodegenerative disorders over the age of 65 years old. Although several underlying mechanisms for explaining the pathogenesis of AD are elucidated, the effective supplements or drugs for the intervention of AD are still limited. [...]

Authors: Mokhtari RB, Baluch N, Homayouni TS, Kumar S, Yeger H PMID: 28735362 PMCID: PMC5842175 DOI: 10.1007/s12079-017-0401-y Abstract Cancer is a multi-stage process resulting from aberrant signaling pathways driving uncontrolled proliferation of transformed cells. The development and progression of cancer from a premalignant lesion towards a metastatic tumor requires accumulation of mutations in many regulatory [...]

Authors: Lee CR, Zeldin DC PMID: 26605933 PMCID: PMC5512422 doi: 10.1056/NEJMcibr1511280 Abstract Severe sepsis remains a major public health problem associated with poor clinical outcomes and substantial health care expenditures. Although the number of sepsis cases in the United States exceeds 750,000 per year and sepsis is associated with an estimated mortality rate of 20–30%, [...]

Authors: Patel AB, Theoharides TC PMID: 28404689 DOI: 10.1124/jpet.117.240564 Abstract Mast cells (MCs) are critical for allergic reactions but are also important in inflammatory processes. Stimulation by neuropeptides, such as substance P (SP) and neurotensin (NT), leads to release of preformed molecules stored in numerous MC secretory granules and newly synthesized proinflammatory mediators, including tumor [...]

Authors: Larsson P, Alwis I, Niego B, Glise L, Daglas M, Jackson SP PMID: 27706906 DOI: 10.1111/jth.13527 Abstract Essentials Stimulating endogenous fibrinolysis could be a novel antithrombotic strategy. The effect of valproic acid on endothelial tissue plasminogen activator in mice was investigated. Valproic acid increased tissue plasminogen activator expression in vascular endothelium. Valproic acid reduced [...]

Authors: Fung J, Moore J Abstract Thousands of books have been written about the latest and greatest diets that will help people lose weight and improve health. But a key element in any successful nutritional health program is a tried-and-true method that most people haven’t thought about—yet it could be revolutionary for taking health to [...]

Authors: Kim JK, Park SU PMID: 28096787 PMCID: PMC522573 doi: 10.17179/excli2016-485 Abstract Sulforaphane [SFN: 1-isothiocyanato-4-(methylsulfinyl)butane] belongs to the isothiocyanate class of phytochemicals. Glucoraphanin, a glucosinolate precursor of SFN, is a glucosinolate found in cruciferous vegetables such as broccoli, cabbage, cauliflower, and kale. All glucosinolates are composed of a basic structure consisting of a β-D-thioglucose group, [...]

Authors: Mogil RJ, Kaste SC, Ferry RJ, Hudson MM, Howell CR PMID: 26967465 PMCID: PMC4945422 DOI: 10.1001/jamaoncol.2015.6557 Abstract Importance: Bone accrual during youth is critical to establish sufficient strength for lifelong skeletal health. Children with cancer may develop low bone mineral density (BMD) any time before or after diagnosis. Objective: To evaluate the ability of [...]

Authors: Park D, Jeong H, Lee MN, Koh A, Kwon O, Yang YR et al. PMID: 26902888 PMCID: PMC4763238 DOI: 10.1038/srep21772 Abstract Resveratrol (RSV) is a natural polyphenol that has a beneficial effect on health, and resveratrol-induced autophagy has been suggested to be a key process in mediating many beneficial effects of resveratrol, such as [...]