Authors: Shi Z, Puyo CA PMID: 33177829 PMCID: PMC7649937 DOI: 10.2147/TCRM.S273700 Abstract The novel coronavirus disease (COVID-19) is caused by a virus (SARS-Cov-2) and is known for inducing multisystem organ dysfunction associated with significant morbidity and mortality. Current therapeutic strategies for COVID-19 have failed to effectively reduce mortality rate, especially for elderly patients. A newly [...]

Authors: Magro CM, Mulvey JJ, Laurence J, seshan S, Crowson AN, Harp J PMID: 33058948 PMCID: PMC7550120 DOI: 10.1016/j.humpath.2020.10.002 Abstract The purpose of this study was to examine the deltoid skin biopsy in twenty-three patients with coronavirus disease 2019 (COVID-19), most severely ill, for vascular complement deposition and correlate this with severe acute respiratory syndrome [...]

Authors: Sanabria-Mazo JP, Montero-Marin J, Feliu-Soler A, Gasion V, Navarro-Gil M PMID: 33050630 PMCID: PMC7599726 DOI: 10.3390/jcm9103246 Abstract The lack of highly effective treatments for fibromyalgia (FM) represents a great challenge for public health. The objective of this parallel, pilot randomized controlled trial (RCT) was two-fold: (1) to analyze the clinical effects of mindfulness plus [...]

Authors: Andreakos E, Papadaki M, Serhan CN PMID: 32956495 PMCID: PMC7537007 DOI: 10.1111/all.14595 Abstract Coronavirus disease-19 (COVID-19) is a new disease caused by SARS-CoV-2. Since the beginning of 2020, it has become one of the main challenges of our times, causing a high incidence of severe pneumonia, acute respiratory distress syndrome (ARDS), multiorgan failure, and [...]

Authors: Afrin LB, Weinstock LB, Molderings GJ PMID: 32920235 PMCID: PMC7529115 DOI: 10.1016/j.ijid.2020.09.016 Abstract Objectives: One-fifth of Covid-19 patients suffer a severe course of Covid-19 infection; however, the specific causes remain unclear. Mast cells (MCs) are activated by SARS-CoV-2. Although only recently recognized, MC activation syndrome (MCAS), usually due to acquired MC clonality, is a [...]

Authors: Ghosh I, Sankhe R, Mudgal J, Arora D, Nampoothiri M PMID: 32873420 DOI: 10.1016/j.npep.2020.102083 Abstract Spermidine is a naturally occurring endogenous polyamine synthesized from diamine putrescine. It is a well-known autophagy inducer that maintains cellular and neuronal homeostasis. Healthy brain development and function are dependent on brain polyamine concentration. Polyamines interact with the opioid [...]

Authors: Greenhalgh T, Knight M, A'Court C, Buxton M, Husain L PMID: 32784198 DOI: 10.1136/bmj.m3026 Abstract Post-acute covid-19 (“long covid”) seems to be a multisystem disease, sometimes occurring after a relatively mild acute illness.Clinical management requires a whole-patient perspective. This article, intended for primary care clinicians, relates to the patient who has a delayed recovery [...]

Authors: De Flora S, Balansky R, La Maestra S PMID: 32780893 PMCID: PMC7436914 DOI: 10.1096/fj.202001807 Abstract COVID-19 may cause pneumonia, acute respiratory distress syndrome, cardiovascular alterations, and multiple organ failure, which have been ascribed to a cytokine storm, a systemic inflammatory response, and an attack by the immune system. Moreover, an oxidative stress imbalance has [...]

Authors: Prescott HC, Girard TD doi:10.1001/jama.2020.14103 Abstract As of July 30, 2020, more than 17 million people worldwide have been diagnosed with coronavirus disease 2019 (COVID-19), and more than 665 000 have died. In many countries, the rate of diagnosis continues to increase; for example, more than 50 000 new cases per day were reported in the [...]

Authors: Lu Y, Li X, Geng D, Mei N, Wu PY, Huang CC PMID: 32838240 PMCID: PMC7396952 DOI: 10.1016/j.eclinm.2020.100484 Abstract Background: Increasing evidence supported the possible neuro-invasion potential of SARS-CoV-2. However, no studies were conducted to explore the existence of the micro-structural changes in the central nervous system after infection. We [...]