Authors: Arthur JM, Forrest JC, Boehme KW, Kennedy JL, Owens S, Liu J PMID: 34478478 PMCID: PMC8415618 DOI: 10.1371/journal.pone.0257016 Abstract Background: Activation of the immune system is implicated in the Post-Acute Sequelae after SARS-CoV-2 infection (PASC) but the mechanisms remain unknown. Angiotensin-converting enzyme 2 (ACE2) cleaves angiotensin II (Ang II) resulting in decreased activation of [...]

Authors: Patterson BK, Guevara-Coto J, Yogendra R, Francisco E, Long E, Pise A PMID: 34262570 PMCID: PMC8273732 DOI: 10.3389/fimmu.2021.700782 Abstract Expression of CCR5 and its cognate ligands have been implicated in COVID-19 pathogenesis, consequently therapeutics directed against CCR5 are being investigated. Here, we explored the role of CCR5 and its ligands [...]

Authors: Cuesta-Llavona E, Gomez J, Albaiceta GM, Amado-Rodriguez L, Garcia-Clemente M PMID: 34116286 PMCID: PMC8169316 DOI: 10.1016/j.intimp.2021.107825 Abstract The chemokine receptor CCR5 has been implicated in COVID-19. CCR5 and its ligands are overexpressed in patients. The pharmacological targeting of CCR5 would improve the COVID-19 severity. We sought to investigate the role of the CCR5-Δ32 variant [...]

Authors: Hamilton D, Jensen GS PMID: 33882028 Abstract Objectives: To evaluate the effects of ATP 360, a nutraceutical energy formula, in people experiencing long-term fatigue affecting daily living. To explore the use of ex vivo mitochondrial stress testing to evaluate cellular energy improvements with nutraceutical support. Study design: An open-label study design was used with [...]

Authors: Janiri D, Carfi A, Kotzalidis GD, Bernabei R PMID: 33599709 PMCID: PMC7893542 DOI: 10.1001/jamapsychiatry.2021.0109 Abstract This cross-sectional study analyzes characteristics associated with posttraumatic stress disorder in patients after severe coronavirus disease 2019 (COVID-19). Keywords: COVID-19, PTSD, post traumatic stress disorder Source: https://pubmed.ncbi.nlm.nih.gov/33599709/ Archive: https://archive.is/xmUUh

Authors: Al-Aly Z, Xie Y, Bowe B PMID: 33887749 DOI: 10.1038/s41586-021-03553-9 Abstract The acute clinical manifestations of COVID-19 have been well characterized1,2, but the post-acute sequelae of this disease have not been comprehensively described. Here we use the national healthcare databases of the US Department of Veterans Affairs to systematically and comprehensively identify 6-month incident [...]

Authors: Wallukat G, Hohberger B, Wenzel K, Furst J, Wallukat A PMID: 33880442 PMCID: PMC8049853 DOI: 10.1016/j.jtauto.2021.100100 Abstract Impairment of health after overcoming the acute phase of COVID-19 is being observed more and more frequently. Here different symptoms of neurological and/or cardiological origin have been reported. With symptoms, which are very similar to the ones [...]

Authors: Theoharides TT, Cholevas C, Polyzoidis K, Poliotis A PMID: 33847020 PMCID: PMC8250989 DOI: 10.1002/biof.1726 Abstract COVID-19 leads to severe respiratory problems, but also to long-COVID syndrome associated primarily with cognitive dysfunction and fatigue. Long-COVID syndrome symptoms, especially brain fog, are similar to those experienced by patients undertaking or following chemotherapy for cancer (chemofog or [...]

Authors: Chen Y, Gu S, Chen Y, Lu H, Shi D, Guo J PMID: 33833065 PMCID: PMC8666823 DOI: 10.1136/gutjnl-2021-324090 Abstract We read with great interest the recent article published in Gut in which Yeoh et al demonstrated that gut microbiota composition of recovered patients with COVID-19 remained significantly distinct from uninfected controls. Persisting symptoms, also [...]

Authors: Taquet M, Geddes JR, Husain M, Luciano S, Harrison PJ PMID: 33836148 PMCID: PMC8023694 DOI: 10.1016/S2215-0366(21)00084-5 Abstract Background: Neurological and psychiatric sequelae of COVID-19 have been reported, but more data are needed to adequately assess the effects of COVID-19 on brain health. We aimed to provide robust estimates of incidence rates and relative risks [...]