Auhtors: Wang Q, Shao X, Zhang Y, Zhu M, Wang FXC, Mu J, et al. PMID: 36807772 PMCID: PMC10242329 DOI: 10.1002/cam4.5698 Abstract Cancer is now considered a tumor microenvironment (TME) disease, although it was originally thought to be a cell and gene expression disorder. Over the past 20 years, significant advances have been made in [...]

Auhtors: Cole K, Al-Kadhimi Z, Talmadge JE PMID: 36640224 PMCID: PMC9840433 DOI: 10.1007/s10555-023-10079-1 Abstract The establishment of primary tumor cells in distant organs, termed metastasis, is the principal cause of cancer mortality and is a crucial therapeutic target in oncology. Thus, it is critical to establish a better understanding of metastatic progression for the future [...]

Auhtors: American Cancer Society Abstract Cancer Facts & Figures 2023 is an educational companion for Cancer Statistics 2023, a scientific paper published in the American Cancer Society journal, CA: A Cancer Journal for Clinicians. These annual reports provide: Estimated numbers of new cancer cases and deaths in 2023 by cancer site and US state Current [...]

Auhtors: Teicholz N. PMID: 36477384 PMCID: PMC9794145 DOI: 10.1097/MED.0000000000000791 Abstract Purpose of review: This article recounts the history of the diet-heart hypothesis from the late 1950s up to the current day, with revelations that have never before been published in the scientific literature. Insights include the role of authorities in launching the diet-hypothesis, including a [...]

Auhtors: Li XX, Liu C, Dong SL, Ou CS, Lu JL, Ye JH PMID: 36545470 PMCID: PMC9760998 DOI: 10.3389/fnut.2022.1060783 Abstract Catechins are a cluster of polyphenolic bioactive components in green tea. Anticarcinogenic effects of tea catechins have been reported since the 1980s, but it has been controversial. The present paper reviews the advances in studies [...]

Auhtors: Wang X, Ma H, Gupta S, Heianza Y, Fonseca V, Qi L PMID: 35776011 PMCID: PMC9681613 DOI: 10.1210/clinem/dgac401 Abstract Context: Sleep quality has been related to the risk of diabetes; however, little is known about the prevalence of diabetes in the United States according to the levels of sleep quality. Objective: To examine the [...]

Auhtors: Hwang CY, Choe W, Yoon KS, Ha J, Kim SS, Yeo EJ, Kang I PMID: 36432618 PMCID: PMC9694619 DOI: 10.3390/nu14224932 Abstract The ketone bodies (KBs) β-hydroxybutyrate and acetoacetate are important alternative energy sources for glucose during nutrient deprivation. KBs synthesized by hepatic ketogenesis are catabolized to acetyl-CoA through ketolysis in extrahepatic tissues, followed by [...]

Auhtors: Jo SB, Sung SJ, Choi HS, Park J-S, Hong Y-K, Joe YA PMID: 36305295 PMCID: PMC9622313 DOI: 10.4062/biomolther.2022.122 Abstract Mebendazole (MBZ), a microtubule depolymerizing drug commonly used for the treatment of helminthic infections, has been suggested as a repositioning candidate for the treatment of brain tumors. However, the efficacy of MBZ needs further study [...]

Auhtors: Halilton MT, Hamilton D, Zderic TW PMID: 36034224 PMCID: PMC9404652 DOI: 10.1016/j.isci.2022.104869 Abstract Slow oxidative muscle, most notably the soleus, is inherently well equipped with the molecular machinery for regulating blood-borne substrates. However, the entire human musculature accounts for only ∼15% of the body's oxidative metabolism of glucose at the resting energy expenditure, despite [...]

Auhtors: Ma Y, Xu X, Wu H, Li C, Zhong P, Liu Z, et al. PMID: 36116250 DOI: 10.1016/j.biopha.2022.113706 Abstract Ivermectin has been proposed as a potential anti-inflammatory drug in addition to its antiparasitic activity. Here we investigated the potential role of ivermectin in the pathogenesis of acute lung injury (ALI) using the lipopolysaccharide (LPS)- [...]