Authors: Charnley M, Islam S, Bindra G, Ratcliffe J, Zhou J, Hulett M Abstract COVID-19 is primarily known as a respiratory disease caused by SARS-CoV-2. However, neurological symptoms such as memory loss, sensory confusion, severe headaches, and even stroke are reported in up to 30% of cases and can persist even after the infection is [...]

Auhtors: Li J, Fan Y, Zhang Y, Liu Y, Yu Y, Ma M PMID: 35745143 PMCID: PMC9228598 DOI: 10.3390/nu14122413 Abstract Resveratrol (RSV) has been reported to induce autophagy and apoptosis in non-small-cell lung cancer A549 cells, and the nerve growth factor receptor (NGFR) regulates autophagy and apoptosis in many other cells. However, the effect of [...]

Authors: Ma WH, Zhang XG, Guo LL, Zhang JB, Wei FT PMID: 34109585 DOI: 10.26355/eurrev_202105_25944 Abstract Objective: Experimental autoimmune myocarditis (EAM) is characterized by pronounced macrophage infiltration, cardiac necrosis, and cardiac fibrosis. Our previous studies have demonstrated that suppressed androgen receptor (AR) enables anti-inflammation to promote tissue repair by decreasing M1 macrophages and increasing M2 [...]

Auhtors: Mengual D, Medrano LE, Villamizar-Villamizar W, Osorio-Llanes E, Mendoza-Torres E, Bolívar S PMID: 35745567 PMCID: PMC9228383 DOI: 10.3390/ph15060648 Abstract Cancer is one of the main causes of death globally. Most of the molecular mechanisms underlying cancer are marked by complex aberrations that activate the critical cell-signaling pathways that play a pivotal role in cell [...]

Auhtors: Tie Y, Tang F, Wei YQ, Wei XW PMID: 35585567 PMCID: PMC9118588 DOI: 10.1186/s13045-022-01282-8 Abstract Immunotherapies like the adoptive transfer of gene-engineered T cells and immune checkpoint inhibitors are novel therapeutic modalities for advanced cancers. However, some patients are refractory or resistant to these therapies, and the mechanisms underlying tumor immune resistance have not [...]

Authors: Nystrom S, Hammarstrom P PMID: 35579205 PMCID: PMC9136918 DOI: 10.1021/jacs.2c03925 Abstract SARS-CoV-2 infection is associated with a surprising number of morbidities. Uncanny similarities with amyloid-disease associated blood coagulation and fibrinolytic disturbances together with neurologic and cardiac problems led us to investigate the amyloidogenicity of the SARS-CoV-2 spike protein (S-protein). Amyloid fibril assays of peptide [...]

Auhtors: Ligibel JA, Bohlke K, May AM, Clinton SK, Demark-Wahnefried W, Gilchrist SC, et al. PMID: 35576506 DOI: 10.1200/JCO.22.00687 Abstract Purpose: To provide guidance on exercise, diet, and weight management during active cancer treatment in adults. Methods: A systematic review of the literature identified systematic reviews and randomized controlled trials evaluating the impact of aerobic [...]

Auhtors: Ming H, Li B, Tian H, Zhou L, Jian J, Zhang T, et al. PMID: 35634171 PMCID: PMC9130112 DOI: 10.1016/j.mtbio.2022.100289 Abstract Previously used in anti-fungal therapy, itraconazole has now been shown to be successful in treating advanced breast cancer (NCT00798135). However, its poor solubility still restricts its application in clinical treatment. There is therefore [...]

Authors: Mostafa-Hedeab G, Al-kuraishy HM, Al-Gareeb AA, Jeandet P, Saaad HM, El-Saber Batiha G PMID: 35486310 PMCID: PMC9051499 DOI: 10.1007/s10787-022-00993-1 Abstract The existing pandemic viral infection caused by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) leads to coronavirus disease 2019 (Covid-19). SARS-CoV-2 exploits angiotensin-converting enzyme 2 (ACE2) as an entry-point into affected cells and [...]

Authors: Gupta K, Strymish J, Stack G, Chamess M DOI: https://doi.org/10.21203/rs.3.rs-1588371/v1 Abstract Initiation of NM/R treatment on Day 0 in a 71-year-old vaccinated and boosted male resulted in rapid resolution of COVID-19 symptoms followed one week later by the development of typical cold symptoms. SARS-CoV-2 viral load fluctuated in parallel with symptoms, with two distinct [...]