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The pathogenesis of a COVID-19 respiratory infection, in a major way, is related to what is referred to as the cytokine storm [cytokine storm syndrome (CSS, hypercytokinemia, etc.], i.e., it is a hyper-inflammatory response.
Categories: I-PREVENT
Auhtors: Chen Y, Cairns R, Papandreou I, Koong A, Denko NC PMID: 19753307 PMCID: PMC2737639 DOI: 10.1371/journal.pone.0007033 Abstract Background: The unique metabolism of tumors was described many years ago by Otto Warburg, who identified tumor cells with increased glycolysis and decreased mitochondrial activity. However, "aerobic glycolysis" generates fewer ATP per glucose molecule than mitochondrial oxidative [...]
Categories: Cancer Care
Tags: Tumor, Warburg effect
Auhtors: Vander Heiden MG, Cantley LC, Thompson CB PMID: 19460998 PMCID: PMC2849637 DOI: 10.1126/science.1160809 Abstract In contrast to normal differentiated cells, which rely primarily on mitochondrial oxidative phosphorylation to generate the energy needed for cellular processes, most cancer cells instead rely on aerobic glycolysis, a phenomenon termed "the Warburg effect." Aerobic glycolysis is an inefficient [...]
Categories: Cancer Care
Tags: Cancer, Warburg effect
Auhtors: Mathupala SP, Ko YH, Pedersen PL PMID: 19101634 PMCID: PMC2714668 DOI: 10.1016/j.semcancer.2008.11.006 Abstract The most common metabolic hallmark of malignant tumors, i.e., the "Warburg effect" is their propensity to metabolize glucose to lactic acid at a high rate even in the presence of oxygen. The pivotal player in this frequent cancer phenotype is mitochondrial-bound [...]
Categories: Cancer Care