Authors: Pitt B, Sutton NR, Wang Z, Holinstat M PMID: 33667455 PMCID: PMC7923868 DOI: 10.1016/j.ejphar.2021.173988 Abstract There is a need for therapeutic approaches to prevent and mitigate the effects of Coronavirus Disease (2019) (COVID-19). The histone deacetylase (HDAC) inhibitor valproic acid, which has been available for the therapy of epilepsy for many years, is a [...]

Authors: Andreu S, Ripa I, Bello-Morales R, Lopez-Guerrero JA PMID: 33256172 PMCID: PMC7760627 DOI: 10.3390/v12121356 Abstract Herpes simplex viruses (HSVs) are neurotropic viruses with broad host range whose infections cause considerable health problems in both animals and humans. In fact, 67% of the global population under the age of 50 are infected with HSV-1 and [...]

Authors: Unal G, Turan B, Balcioglu YH PMID: 32498007 PMCID: PMC7255327 DOI: 10.1016/j.mehy.2020.109891 Abstract Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) which leads to COVID-19, was first seen in Wuhan province of China in December 2019 and spread globally in a short time. COVID-19 was announced as a pandemic by WHO on March 11th, 2020 and approximately [...]

Authors: Larsson P, Alwis I, Niego B, Glise L, Daglas M, Jackson SP PMID: 27706906 DOI: 10.1111/jth.13527 Abstract Essentials Stimulating endogenous fibrinolysis could be a novel antithrombotic strategy. The effect of valproic acid on endothelial tissue plasminogen activator in mice was investigated. Valproic acid increased tissue plasminogen activator expression in vascular endothelium. Valproic acid reduced [...]

Authors: Gorres KL, Daigle D, Mohanram S, Mcinerney GE, Lyons DE PMID: 26933051 PMCID: PMC4810481 DOI: 10.1128/mBio.00113-16 Abstract Reactivation of Epstein-Barr virus (EBV) from latency into the lytic phase of its life cycle allows the virus to spread among cells and between hosts. Valproic acid (VPA) inhibits initiation of the lytic cycle in EBV-infected B [...]