Authors: Rosas IO, Brau N, Waters M, Go R, Hunter BD, Bhagani S et al. PMID: 33631066 PMCID: PMC7953459 DOI: 10.1056/NEJMoa2028700 Abstract Background: Coronavirus disease 2019 (Covid-19) is associated with immune dysregulation and hyperinflammation, including elevated interleukin-6 levels. The use of tocilizumab, a monoclonal antibody against the interleukin-6 receptor, has resulted in better outcomes in [...]

Authors: Salvarani C, Dolci G, Massari M, Merlo DF, Cavuto S PMID: 33080005 PMCID: PMC7577199 DOI: 10.1001/jamainternmed.2020.6615 Abstract Importance: The coronavirus disease 2019 (COVID-19) pandemic is threatening billions of people worldwide. Tocilizumab has shown promising results in retrospective studies in patients with COVID-19 pneumonia with a good safety profile. Objective: To evaluate the effect of [...]

Authors: Hermine O, Mariette X, Tharaux PL, Resche-Rignon M, Porcher R PMID: 33080017 PMCID: PMC7577198 DOI: 10.1001/jamainternmed.2020.6820 Abstract Importance: Severe pneumonia with hyperinflammation and elevated interleukin-6 is a common presentation of coronavirus disease 2019 (COVID-19). Objective: To determine whether tocilizumab (TCZ) improves outcomes of patients hospitalized with moderate-to-severe COVID-19 pneumonia. Design, setting, and particpants: This [...]

Authors: Salama C, Han J, Yau L, Reiss WG, Kramer B PMID: 33332779 PMCID: PMC7781101 DOI: 10.1056/NEJMoa2030340 Abstract Background: Coronavirus disease 2019 (Covid-19) pneumonia is often associated with hyperinflammation. Despite the disproportionate incidence of Covid-19 among underserved and racial and ethnic minority populations, the safety and efficacy of the anti-interleukin-6 receptor antibody tocilizumab in patients [...]

Authors: Stone JH, Frigault MJ, Sterling-Boyd NJ, Fernandes AD, Harvey FL PMID: 33085857 PMCID: PMC7646626 DOI: 10.1056/NEJMoa2028836 Abstract Background: The efficacy of interleukin-6 receptor blockade in hospitalized patients with coronavirus disease 2019 (Covid-19) who are not receiving mechanical ventilation is unclear. Methods: We performed a randomized, double-blind, placebo-controlled trial involving patients with confirmed severe acute [...]