Auhtors: Li C, Jiang P, Wei S, Xu X, Wang J PMID: 32680511 PMCID: PMC7367382 DOI: 10.1186/s12943-020-01234-1 Abstract Regulatory T cells (Tregs) characterized by the expression of the master transcription factor forkhead box protein p3 (Foxp3) suppress anticancer immunity, thereby hindering protective immunosurveillance of tumours and hampering effective antitumour immune responses in tumour-bearing hosts, constitute [...]

Auhtors: Raffin C, Vo LT, Bluestone JA PMID: 31811270 PMCID: PMC7814338 DOI: 10.1038/s41577-019-0232-6 Abstract Cellular therapies using regulatory T (Treg) cells are currently undergoing clinical trials for the treatment of autoimmune diseases, transplant rejection and graft-versus-host disease. In this Review, we discuss the biology of Treg cells and describe new efforts in Treg cell engineering [...]

Auhtors: Ohue Y, Nishikawa H PMID: 31102428 PMCID: PMC6609813 DOI: 10.1111/cas.14069 Abstract Regulatory T (Treg) cells suppress abnormal/excessive immune responses to self- and nonself-antigens to maintain immune homeostasis. In tumor immunity, Treg cells are involved in tumor development and progression by inhibiting antitumor immunity. There are several Treg cell immune suppressive mechanisms: inhibition of costimulatory [...]

Auhtors: Sharabi A, tsokos MG, Ding Y, Malek TR, Klatzmann D, Tsokos GC PMID: 30310234 DOI: 10.1038/nrd.2018.148 Abstract Regulatory T (Treg) cells suppress inflammation and regulate immune system activity. In patients with systemic or organ-specific autoimmune diseases or those receiving transplanted organs, Treg cells are compromised. Approaches to strengthen Treg cell function, either by expanding [...]

Auhtors: Knochelmann HM, Dwyer CJ, Bailey SR, Amaya SM, Elston DM, Mazza-McCrann JM, Paulos CM PMID: 29563615 PMCID: PMC6068176 DOI: 10.1038/s41423-018-0004-4 Abstract The balance between Th17 cells and regulatory T cells (Tregs) has emerged as a prominent factor in regulating autoimmunity and cancer. Th17 cells are vital for host defense against pathogens but have also [...]

Auhtors: Pan PY, Ma G, Weber KJ, Ozao-Choy J, Wang G, Yin B, et al. PMID: 19996287 PMCID: PMC2805053 DOI: 10.1158/0008-5472.CAN-09-1882 Abstract Immune tolerance to tumors is often associated with accumulation of myeloid-derived suppressor cells (MDSC) and an increase in the number of T-regulatory cells (Treg). In tumor-bearing mice, MDSCs can themselves facilitate the generation [...]