Authors: Mokhtari RB, Baluch N, Homayouni TS, Kumar S, Yeger H PMID: 28735362 PMCID: PMC5842175 DOI: 10.1007/s12079-017-0401-y Abstract Cancer is a multi-stage process resulting from aberrant signaling pathways driving uncontrolled proliferation of transformed cells. The development and progression of cancer from a premalignant lesion towards a metastatic tumor requires accumulation of mutations in many regulatory [...]

Authors: Kim JK, Park SU PMID: 28096787 PMCID: PMC522573 doi: 10.17179/excli2016-485 Abstract Sulforaphane [SFN: 1-isothiocyanato-4-(methylsulfinyl)butane] belongs to the isothiocyanate class of phytochemicals. Glucoraphanin, a glucosinolate precursor of SFN, is a glucosinolate found in cruciferous vegetables such as broccoli, cabbage, cauliflower, and kale. All glucosinolates are composed of a basic structure consisting of a β-D-thioglucose group, [...]

Authors: Houghton CA, Fassett RG, Coombes JS PMID: 24147970 DOI: 10.1111/nure.12060 Abstract Cruciferous vegetables are widely acknowledged to provide chemopreventive benefits in humans, but they are not generally consumed at levels that effect significant change in biomarkers of health. Because consumers have embraced the notion that dietary supplements may prevent disease, this review considers whether [...]

Authors: Clarke JD, Hsu A, Riedl K, Bella D, Stevens JF, Ho E PMID: 21816223 PMCID: PMC3183106 DOI: 10.1016/j.phrs.2011.07.005 Abstract Broccoli consumption may reduce the risk of various cancers and many broccoli supplements are now available. The bioavailability and excretion of the mercapturic acid pathway metabolites isothiocyanates after human consumption of broccoli supplements has not [...]