Authors: Freitag K, Sterczyk N, Wendlinger S, Schulz J, Ralser M, Fleck L et al. PMID: 35780157 PMCID: PMC9250727 DOI: 10.1186/s12974-022-02534-7 Abstract Background: Deposition of amyloid beta (Aβ) and hyperphosphorylated tau along with glial cell-mediated neuroinflammation are prominent pathogenic hallmarks of Alzheimer's disease (AD). In recent years, impairment of autophagy has been identified as another [...]

Authors: Schroeder S, Hofer S, Zimmermann A, Pechlaner R, Pendl T, Bergmann M et al. PMID: 33852843 DOI: 10.1016/j.celrep.2021.108985 Abstract Decreased cognitive performance is a hallmark of brain aging, but the underlying mechanisms and potential therapeutic avenues remain poorly understood. Recent studies have revealed health-protective and lifespan-extending effects of dietary spermidine, a natural autophagy-promoting polyamine. [...]

Authors: Ghosh I, Sankhe R, Mudgal J, Arora D, Nampoothiri M PMID: 32873420 DOI: 10.1016/j.npep.2020.102083 Abstract Spermidine is a naturally occurring endogenous polyamine synthesized from diamine putrescine. It is a well-known autophagy inducer that maintains cellular and neuronal homeostasis. Healthy brain development and function are dependent on brain polyamine concentration. Polyamines interact with the opioid [...]

Authors: Gassen NC, Papies J, Bajaj T, Emanuel J, Wechmann K, Heinz DE et al. doi: https://doi.org/10.1101/2020.04.15.997254 Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses an acute threat to public health and the world economy, especially because no approved specific drugs or vaccines are available. Pharmacological modulation of metabolism-dependent cellular pathways such as autophagy [...]

Authors: Xu TT, Li H, Dai Z, Lau GK, Li BY, Zhu WL et al. PMID: 32268299 PMCID: PMC7185103 DOI: 10.18632/aging.103035 Abstract The natural polyamine spermidine and spermine have been reported to ameliorate aging and aging-induced dementia. However, the mechanism is still confused. An aging model, the senescence accelerated mouse-8 (SAMP8), was used in this [...]

Authors: Kiechl S, Pechlaner R, Willeit P, Notdurfier M, Paulweber B, Willeit K et al. PMID: 29955838 DOI: 10.1093/ajcn/nqy102 Abstract Background: Spermidine administration is linked to increased survival in several animal models. Objective: The aim of this study was to test the potential association between spermidine content in diet and mortality in humans. Design: This [...]

Authors: LaRocca TJ, Gioscia-Ryan RA, Hearon CM, Seals DR PMID: 23612189 PMCID: PMC3700669 DOI: 10.1016/j.mad.2013.04.004 Abstract Arterial aging, characterized by stiffening of large elastic arteries and the development of arterial endothelial dysfunction, increases cardiovascular disease (CVD) risk. We tested the hypothesis that spermidine, a nutrient associated with the anti-aging process autophagy, [...]

Authors: Minois N, Bauer MA, Rockenfeller P, Eisneber T, Brandhorst S, Kroemer G PMID: 23059820 PMCID: PMC3481127 doi: 10.1038/cddis.2012.139 Abstract The naturally occurring polyamine spermidine (Spd) has recently been shown to promote longevity across species in an autophagy-dependent manner. Here, we demonstrate that Spd improves both survival and locomotor activity of the fruit fly Drosophila [...]

Authors: Morselli E, Marino G, Bennetzen MV, Eisenberg T, Megalou E, Schroeder S et al. PMID: 21339330 PMCID: PMC3044119 DOI: 10.1083/jcb.201008167 Abstract Autophagy protects organelles, cells, and organisms against several stress conditions. Induction of autophagy by resveratrol requires the nicotinamide adenine dinucleotide-dependent deacetylase sirtuin 1 (SIRT1). In this paper, we show that the acetylase inhibitor [...]

Authors: Morselli E, Galluzzi L, Kepp O, Criollo A, Maiuri MC, Madeo F PMID: 20157579 PMCID: PMC2815753 DOI: 10.18632/aging.100110 Abstract Although autophagy has widely been conceived as a self-destructive mechanism that causes cell death, accumulating evidence suggests that autophagy usually mediates cytoprotection, thereby avoiding the apoptotic or necrotic demise of stressed cells. Recent evidence produced [...]